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dc.contributor.authorPark, Jin-Sung
dc.contributor.authorMehta, Prachi
dc.contributor.authorCooper, Antony A
dc.contributor.authorVeivers, David
dc.contributor.authorHeimbach, Andre
dc.contributor.authorStiller, Barbara
dc.contributor.authorKubisch, Christian
dc.contributor.authorFung, Victor S
dc.contributor.authorKrainc, Dimitri
dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorSue, Carolyn M
dc.date.accessioned2017-05-03T11:32:36Z
dc.date.available2017-05-03T11:32:36Z
dc.date.issued2011
dc.date.modified2012-02-14T04:10:47Z
dc.identifier.issn1059-7794
dc.identifier.doi10.1002/humu.21527
dc.identifier.urihttp://hdl.handle.net/10072/42566
dc.description.abstractMost brain diseases arise from interactions between complex genetic and environmental risk factors. Finding biomarkers for brain diseases will require appropriate cellular models to identify dysregulated cell functions and diseaseassociated biochemistries. Patient-derived stem cells hold great potential as models of brain diseases. Stem cells can proliferate and can be banked, stored, and thawed for genomic, proteomic, and functional studies. Patient-derived, induced pluripotent stem cells and adult stem cells from the olfactory organ in the nose are already giving novel insights into a number of brain diseases, including Parkinson's disease and schizophrenia. Biomarker discovery may be possible from investigating disease-associated cell biologies in patient-derived stem cells.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherJohn Wiley & Sons Inc.
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom956
dc.relation.ispartofpageto964
dc.relation.ispartofissue8
dc.relation.ispartofjournalHuman Mutation
dc.relation.ispartofvolume32
dc.rights.retentionY
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode1103
dc.titlePathogenic Effects of Novel Mutations in the P-Type ATPase ATP13A2 (PARK9) Causing Kufor-Rakeb Syndrome, a Form of Early-Onset Parkinsonism
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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