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dc.contributor.authorWedlock, Louiseen_US
dc.contributor.authorBerners-Price, Sueen_US
dc.date.accessioned2017-04-24T08:48:33Z
dc.date.available2017-04-24T08:48:33Z
dc.date.issued2011en_US
dc.identifier.issn00049425en_US
dc.identifier.urihttp://hdl.handle.net/10072/42567
dc.description.abstracthere are increasing reports of novel metal-based chemotherapeutics that have either improved cancer cell selectivity, or alternative mechanisms of action, to existing anticancer drugs, and techniques are required for determining their sub-cellular molecular targets. Imaging methods offer many distinct advantages over destructive fractionation techniques, including the preservation of useful morphological information; however, mapping the intracellular distribution of metal ions inside tumour cells still remains challenging. Recent advances in three modes of imaging are discussed in this review, with a particular focus on the application to metal-based cancer chemotherapy - fluorescence microscopy, electron microscopy (including energy-filtered transmission electron microscopy (EFTEM)), and a new technique, Nano-scale secondary ion mass spectrometry (NanoSIMS).en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherCSIRO Publishingen_US
dc.publisher.placeAustraliaen_US
dc.publisher.urihttp://www.publish.csiro.au/paper/CH11132.htmen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom692en_US
dc.relation.ispartofpageto704en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalAustralian Journal of Chemistryen_US
dc.relation.ispartofvolume64en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBioinorganic Chemistryen_US
dc.subject.fieldofresearchcode030201en_US
dc.titleRecent advances in mapping the sub-cellular distribution of metal-based anticancer drugsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2015-05-21T02:43:37Z
gro.hasfulltextNo Full Text


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