Synthesis of a novel pentasaccharide core component from the lipooligosaccharide of Moraxella catarrhalis
Author(s)
Pearson, Andrew G
Peak, Ian R
Wilson, Jennifer C
Grice, I Darren
Year published
2011
Metadata
Show full item recordAbstract
The novel pentasaccharide [p-(trifluoroacetamido)phenyl]ethyl 3-O-b-D-glucopyranosyl-4-O-b-D-glucopyranosyl-6-O-[2-O-(a-D-glucopyranosyl)-b-D-glucopyranosyl]-a-D-glucopyranoside (1), which includes a linker moiety to enable facile coupling to an antigenic protein, was synthesised as a component of a potential vaccine candidate against the Gram-negative bacterium Moraxella catarrhalis. This microorganism is one of three principal causative agents of otitis media in children. The pentasaccharide represents a common cross-serotype (A, B and C) structure from the lipooligosaccharides of Moraxella catarrhalis.The novel pentasaccharide [p-(trifluoroacetamido)phenyl]ethyl 3-O-b-D-glucopyranosyl-4-O-b-D-glucopyranosyl-6-O-[2-O-(a-D-glucopyranosyl)-b-D-glucopyranosyl]-a-D-glucopyranoside (1), which includes a linker moiety to enable facile coupling to an antigenic protein, was synthesised as a component of a potential vaccine candidate against the Gram-negative bacterium Moraxella catarrhalis. This microorganism is one of three principal causative agents of otitis media in children. The pentasaccharide represents a common cross-serotype (A, B and C) structure from the lipooligosaccharides of Moraxella catarrhalis.
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Journal Title
Carbohydrate Research
Volume
346
Issue
17
Subject
Medicinal and biomolecular chemistry
Medicinal and biomolecular chemistry not elsewhere classified
Organic chemistry
Organic chemistry not elsewhere classified
Biochemistry and cell biology