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  • Synthesis of a novel pentasaccharide core component from the lipooligosaccharide of Moraxella catarrhalis

    Author
    Pearson, Andrew
    Peak, Ian
    Wilson, Jenny
    Grice, Darren
    Year published
    2011
    Metadata
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    Abstract
    The novel pentasaccharide [p-(trifluoroacetamido)phenyl]ethyl 3-O-b-D-glucopyranosyl-4-O-b-D-glucopyranosyl-6-O-[2-O-(a-D-glucopyranosyl)-b-D-glucopyranosyl]-a-D-glucopyranoside (1), which includes a linker moiety to enable facile coupling to an antigenic protein, was synthesised as a component of a potential vaccine candidate against the Gram-negative bacterium Moraxella catarrhalis. This microorganism is one of three principal causative agents of otitis media in children. The pentasaccharide represents a common cross-serotype (A, B and C) structure from the lipooligosaccharides of Moraxella catarrhalis.The novel pentasaccharide [p-(trifluoroacetamido)phenyl]ethyl 3-O-b-D-glucopyranosyl-4-O-b-D-glucopyranosyl-6-O-[2-O-(a-D-glucopyranosyl)-b-D-glucopyranosyl]-a-D-glucopyranoside (1), which includes a linker moiety to enable facile coupling to an antigenic protein, was synthesised as a component of a potential vaccine candidate against the Gram-negative bacterium Moraxella catarrhalis. This microorganism is one of three principal causative agents of otitis media in children. The pentasaccharide represents a common cross-serotype (A, B and C) structure from the lipooligosaccharides of Moraxella catarrhalis.
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    Journal Title
    Carbohydrate Research
    Volume
    346
    Issue
    17
    DOI
    https://doi.org/10.1016/j.carres.2011.10.002
    Subject
    Organic Chemistry not elsewhere classified
    Medicinal and Biomolecular Chemistry not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/42583
    Collection
    • Journal articles

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