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dc.contributor.authorHolmes, Roger S
dc.contributor.authorHempel, John
dc.date.accessioned2017-05-03T14:56:12Z
dc.date.available2017-05-03T14:56:12Z
dc.date.issued2011
dc.date.modified2012-05-27T22:29:55Z
dc.identifier.issn0009-2797
dc.identifier.doi10.1016/j.cbi.2011.01.014
dc.identifier.urihttp://hdl.handle.net/10072/42603
dc.description.abstractMammalian ALDH3 genes (ALDH3A1, ALDH3A2, ALDH3B1 and ALDH3B2) encode enzymes of peroxidic and fatty aldehyde metabolism. ALDH3A1 also plays a major role in anterior eye tissue UV-filtration. BLAT and BLAST analyses were undertaken of several vertebrate genomes using rat, chicken and zebrafish ALDH3-like amino acid sequences. Predicted vertebrate ALDH3 sequences and structures were highly conserved, including residues involved in catalysis, coenzyme binding and enzyme structure as reported by Liu et al. [27] for rat ALDH3A1. Phylogeny studies of human, rat, opossum, platypus, chicken, xenopus and zebrafish ALDH3-like sequences supported three hypotheses: (1) the mammalian ALDH3A1 gene was generated by a tandem duplication event of an ancestral vertebrate ALDH3A2 gene; (2) multiple mammalian and chicken ALDH3B-like genes were generated by tandem duplication events within genomes of related species; and (3) vertebrate ALDH3A and ALDH3B genes were generated prior to the appearance of bony fish more than 500 million years ago.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1266026 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom113
dc.relation.ispartofpageto121
dc.relation.ispartofissue1-3
dc.relation.ispartofjournalChemico-Biological Interactions
dc.relation.ispartofvolume191
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310509
dc.titleComparative studies of vertebrate aldehyde dehydrogenase 3: Sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2011 Elsevier Ireland Ltd.. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorHolmes, Roger S.


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