dc.contributor.author | Holmes, Roger S | |
dc.contributor.author | Hempel, John | |
dc.date.accessioned | 2017-05-03T14:56:12Z | |
dc.date.available | 2017-05-03T14:56:12Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2012-05-27T22:29:55Z | |
dc.identifier.issn | 0009-2797 | |
dc.identifier.doi | 10.1016/j.cbi.2011.01.014 | |
dc.identifier.uri | http://hdl.handle.net/10072/42603 | |
dc.description.abstract | Mammalian ALDH3 genes (ALDH3A1, ALDH3A2, ALDH3B1 and ALDH3B2) encode enzymes of peroxidic and fatty aldehyde metabolism. ALDH3A1 also plays a major role in anterior eye tissue UV-filtration. BLAT and BLAST analyses were undertaken of several vertebrate genomes using rat, chicken and zebrafish ALDH3-like amino acid sequences. Predicted vertebrate ALDH3 sequences and structures were highly conserved, including residues involved in catalysis, coenzyme binding and enzyme structure as reported by Liu et al. [27] for rat ALDH3A1. Phylogeny studies of human, rat, opossum, platypus, chicken, xenopus and zebrafish ALDH3-like sequences supported three hypotheses: (1) the mammalian ALDH3A1 gene was generated by a tandem duplication event of an ancestral vertebrate ALDH3A2 gene; (2) multiple mammalian and chicken ALDH3B-like genes were generated by tandem duplication events within genomes of related species; and (3) vertebrate ALDH3A and ALDH3B genes were generated prior to the appearance of bony fish more than 500 million years ago. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 1266026 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Ireland | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 113 | |
dc.relation.ispartofpageto | 121 | |
dc.relation.ispartofissue | 1-3 | |
dc.relation.ispartofjournal | Chemico-Biological Interactions | |
dc.relation.ispartofvolume | 191 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Genomics | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 310509 | |
dc.title | Comparative studies of vertebrate aldehyde dehydrogenase 3: Sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2011 Elsevier Ireland Ltd.. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. | |
gro.date.issued | 2011 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Holmes, Roger S. | |