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dc.contributor.authorR. Farina, Antoniettaen_US
dc.contributor.authorCappabianca, Luciaen_US
dc.contributor.authorDeSantis, Giuseppinaen_US
dc.contributor.authorIanni, Nataliaen_US
dc.contributor.authorRuggeri, Pierdomenicoen_US
dc.contributor.authorRagone, Marziaen_US
dc.contributor.authorMerolle, Stefaniaen_US
dc.contributor.authorTonissen, Kathrynen_US
dc.contributor.authorGulino, Albertoen_US
dc.contributor.authorMackay, Andrew R.en_US
dc.contributor.editorFelix Wielanden_US
dc.date.accessioned2017-05-03T13:22:19Z
dc.date.available2017-05-03T13:22:19Z
dc.date.issued2011en_US
dc.date.modified2012-02-14T05:36:15Z
dc.identifier.issn00145793en_US
dc.identifier.doi10.1016/j.febslet.2011.09.023en_US
dc.identifier.urihttp://hdl.handle.net/10072/42606
dc.description.abstractIncreased expression of thioredoxin (Trx)-1 and matrix metalloproteinase (MMP)-9 associates with malignant breast cancer progression. Here, we describe a functional relationship between Trx-1 and MMP-9 in promoting MDA-MB-231 breast cancer cell invasive behaviour. Trx-1 overexpression stimulated MMP-9 expression, de-regulated the MMP-9/TIMP-1 equilibrium and augmented MMP-9 involvement in a more invasive phenotype. Trx-1 augmented MMP-9 transcription through NF-B, AP-1 and SP1 elements; stimulated p50/p65 NF-kB activity and recruitment to the MMP-9 promoter; and facilitated MMP-9 promoter-accessibility to NF-kB by preventing HDAC recruitment and maintaining MMP-9 promoter histone acetylation. Our data provide a functional basis for Trx-1 and MMP-9 association in malignant breast cancer and identify Trx-1 and NF-kB as potentially druggable targets for reducing MMP-9 involvement in malignant behaviour.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom3328en_US
dc.relation.ispartofpageto3336en_US
dc.relation.ispartofissue20en_US
dc.relation.ispartofjournalFEBS Lettersen_US
dc.relation.ispartofvolume585en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCancer Cell Biologyen_US
dc.subject.fieldofresearchCellular Interactions (incl. Adhesion, Matrix, Cell Wall)en_US
dc.subject.fieldofresearchcode111201en_US
dc.subject.fieldofresearchcode060106en_US
dc.titleThioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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