dc.contributor.author | Farina, Antonietta R | |
dc.contributor.author | Cappabianca, Lucia | |
dc.contributor.author | DeSantis, Giuseppina | |
dc.contributor.author | Di Ianni, Natalia | |
dc.contributor.author | Ruggeri, Pierdomenico | |
dc.contributor.author | Ragone, Marzia | |
dc.contributor.author | Merolle, Stefania | |
dc.contributor.author | Tonissen, Kathryn F | |
dc.contributor.author | Gulino, Alberto | |
dc.contributor.author | Mackay, Andrew R | |
dc.contributor.editor | Felix Wieland | |
dc.date.accessioned | 2017-05-03T13:22:19Z | |
dc.date.available | 2017-05-03T13:22:19Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2012-02-14T05:36:15Z | |
dc.identifier.issn | 0014-5793 | |
dc.identifier.doi | 10.1016/j.febslet.2011.09.023 | |
dc.identifier.uri | http://hdl.handle.net/10072/42606 | |
dc.description.abstract | Increased expression of thioredoxin (Trx)-1 and matrix metalloproteinase (MMP)-9 associates with malignant breast cancer progression. Here, we describe a functional relationship between Trx-1 and MMP-9 in promoting MDA-MB-231 breast cancer cell invasive behaviour. Trx-1 overexpression stimulated MMP-9 expression, de-regulated the MMP-9/TIMP-1 equilibrium and augmented MMP-9 involvement in a more invasive phenotype. Trx-1 augmented MMP-9 transcription through NF-B, AP-1 and SP1 elements; stimulated p50/p65 NF-kB activity and recruitment to the MMP-9 promoter; and facilitated MMP-9 promoter-accessibility to NF-kB by preventing HDAC recruitment and maintaining MMP-9 promoter histone acetylation. Our data provide a functional basis for Trx-1 and MMP-9 association in malignant breast cancer and identify Trx-1 and NF-kB as potentially druggable targets for reducing MMP-9 involvement in malignant behaviour. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Netherlands | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 3328 | |
dc.relation.ispartofpageto | 3336 | |
dc.relation.ispartofissue | 20 | |
dc.relation.ispartofjournal | FEBS Letters | |
dc.relation.ispartofvolume | 585 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Cellular interactions (incl. adhesion, matrix, cell wall) | |
dc.subject.fieldofresearch | Evolutionary biology | |
dc.subject.fieldofresearch | Cancer cell biology | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 310105 | |
dc.subject.fieldofresearchcode | 3104 | |
dc.subject.fieldofresearchcode | 321101 | |
dc.title | Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2011 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Tonissen, Kathryn F. | |