An efficient approach to 2,5-anhydro-glucitol-based 1'-homo-N-nucleoside mimetics
Author(s)
Bhatt, Beenu
Thomson, Robin J
von Itzstein, Mark
Year published
2011
Metadata
Show full item recordAbstract
This Letter describes an efficient synthesis of a range of 10-homo-N-nucleoside mimetics with a series of 4-substituted 1,2,3-triazoles replacing the natural nucleobase. The synthesis of 6-O-monosulfated 10- homo-N-nucleoside mimetic derivatives is also discussed.This Letter describes an efficient synthesis of a range of 10-homo-N-nucleoside mimetics with a series of 4-substituted 1,2,3-triazoles replacing the natural nucleobase. The synthesis of 6-O-monosulfated 10- homo-N-nucleoside mimetic derivatives is also discussed.
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Journal Title
Tetrahedron Letters
Volume
52
Issue
21
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Organic chemical synthesis
Biochemistry and cell biology