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  • Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran

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    Author(s)
    Arababadi, Mohammad Kazemi
    Mirzaei, Mohammad Reza
    Sajadi, Seyed Mohammad Ali
    Hassanshahi, Gholamhossein
    Ahmadabadi, Behzad Nasiri
    Salehabadi, Vajihe Akbarpour
    Derakhshan, Reza
    Kennedy, Derek
    Griffith University Author(s)
    Kennedy, Derek D.
    Year published
    2012
    Metadata
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    Abstract
    The impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed that single-nucleotide polymorphisms within the -592 region of interleukin-10 (IL-10) are associated with the regulation of its expression. In this study, we aimed to find polymorphisms of this region that may be associated to type 2 diabetic (T2D) patients with and without nephropathy. In this study, peripheral blood samples were ...
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    The impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed that single-nucleotide polymorphisms within the -592 region of interleukin-10 (IL-10) are associated with the regulation of its expression. In this study, we aimed to find polymorphisms of this region that may be associated to type 2 diabetic (T2D) patients with and without nephropathy. In this study, peripheral blood samples were collected from 100 T2D patients without nephropathy, 100 T2D patients with nephropathy, and 100 healthy controls. DNA was extracted, and a polymerase chain reaction-restriction fragment length polymorphism technique was performed to examine the polymorphisms within the -592 region of the IL-10 gene. Our results showed a significant difference between the genotypes and alleles of the -592 region of IL-10 in nephropathic and non-nephropathic patients in comparison to the healthy controls. The differences between the two patient groups in relation to genotypes and alleles were not significant. Results of this study suggest that the functional gene polymorphism of IL-10 reported here may play an important role in the pathogenesis of diabetes, but it seems that these polymorphisms do not have an effect on the nephropathic.
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    Journal Title
    Inflammation
    Volume
    35
    Issue
    3
    DOI
    https://doi.org/10.1007/s10753-011-9376-7
    Copyright Statement
    © 2011 Springer Netherlands. This is an electronic version of an article published in Inflammation, Volume 35, Number 3 (2012), 797-802. Inflammation is available online at: http://www.springerlink.com/ with the open URL of your article.
    Subject
    Endocrinology
    Medical genetics (excl. cancer genetics)
    Immunology
    Humoural immunology and immunochemistry
    Publication URI
    http://hdl.handle.net/10072/42648
    Collection
    • Journal articles

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