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dc.contributor.authorArababadi, Mohammad Kazemi
dc.contributor.authorMirzaei, Mohammad Reza
dc.contributor.authorSajadi, Seyed Mohammad Ali
dc.contributor.authorHassanshahi, Gholamhossein
dc.contributor.authorAhmadabadi, Behzad Nasiri
dc.contributor.authorSalehabadi, Vajihe Akbarpour
dc.contributor.authorDerakhshan, Reza
dc.contributor.authorKennedy, Derek
dc.date.accessioned2017-05-03T11:12:33Z
dc.date.available2017-05-03T11:12:33Z
dc.date.issued2012
dc.date.modified2013-09-11T23:28:05Z
dc.identifier.issn0360-3997
dc.identifier.doi10.1007/s10753-011-9376-7
dc.identifier.urihttp://hdl.handle.net/10072/42648
dc.description.abstractThe impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed that single-nucleotide polymorphisms within the -592 region of interleukin-10 (IL-10) are associated with the regulation of its expression. In this study, we aimed to find polymorphisms of this region that may be associated to type 2 diabetic (T2D) patients with and without nephropathy. In this study, peripheral blood samples were collected from 100 T2D patients without nephropathy, 100 T2D patients with nephropathy, and 100 healthy controls. DNA was extracted, and a polymerase chain reaction-restriction fragment length polymorphism technique was performed to examine the polymorphisms within the -592 region of the IL-10 gene. Our results showed a significant difference between the genotypes and alleles of the -592 region of IL-10 in nephropathic and non-nephropathic patients in comparison to the healthy controls. The differences between the two patient groups in relation to genotypes and alleles were not significant. Results of this study suggest that the functional gene polymorphism of IL-10 reported here may play an important role in the pathogenesis of diabetes, but it seems that these polymorphisms do not have an effect on the nephropathic.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent104024 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom797
dc.relation.ispartofpageto802
dc.relation.ispartofissue3
dc.relation.ispartofjournalInflammation
dc.relation.ispartofvolume35
dc.rights.retentionY
dc.subject.fieldofresearchHumoural Immunology and Immunochemistry
dc.subject.fieldofresearchEndocrinology
dc.subject.fieldofresearchMedical Genetics (excl. Cancer Genetics)
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110705
dc.subject.fieldofresearchcode110306
dc.subject.fieldofresearchcode110311
dc.subject.fieldofresearchcode1107
dc.titleInterleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2011 Springer Netherlands. This is an electronic version of an article published in Inflammation, Volume 35, Number 3 (2012), 797-802. Inflammation is available online at: http://www.springerlink.com/ with the open URL of your article.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorKennedy, Derek D.


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