The IL-10 promoter polymorphism at position -592 is correlated with susceptibility to occult HBV infection
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Abstract-Occult hepatitis B infection (OBI) is characterized as a form of hepatitis in which detectable amounts of HBV-DNA can be monitored in the peripheral blood of patients whereas the hepatitis B surface antigen is undetectable. The main aim of this study was to investigate whether there is a relationship between OBI and single nucleotide polymorphisms in the -592 region of the IL-10 gene. In this study, the polymorphism at position -592 of the IL-10 promoter of 57 OBI cases was compared and correlated to that of 100 healthy controls by PCR-RFLP techniques. Our results showed that patient and control groups had significant differences regarding genotypes and alleles of the -592 polymorphism in the IL-10 gene. Based on our results, it can be concluded that the -592 polymorphism within the promoter of the IL-10 gene is associated with OBI.
Copyright 2011 Springer Netherlands. This is an electronic version of an article published in Inflammation, June 2012, Volume 35, Issue 3, pp 818-821. Inflammation is available online at: http://www.springerlink.com/ with the open URL of your article.
Humoural Immunology and Immunochemistry