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  • Stem cell models for biomarker discovery in brain disease

    Author(s)
    Mackay-Sim, Alan
    Mellick, George
    Wood, Stephen
    Griffith University Author(s)
    Mackay-Sim, Alan
    Mellick, George
    Wood, Stephen A.
    Year published
    2011
    Metadata
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    Abstract
    Most brain diseases arise from interactions between complex genetic and environmental risk factors. Finding biomarkers for brain diseases will require appropriate cellular models to identify dysregulated cell functions and diseaseassociated biochemistries. Patient-derived stem cells hold great potential as models of brain diseases. Stem cells can proliferate and can be banked, stored, and thawed for genomic, proteomic, and functional studies. Patient-derived, induced pluripotent stem cells and adult stem cells from the olfactory organ in the nose are already giving novel insights into a number of brain diseases, including ...
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    Most brain diseases arise from interactions between complex genetic and environmental risk factors. Finding biomarkers for brain diseases will require appropriate cellular models to identify dysregulated cell functions and diseaseassociated biochemistries. Patient-derived stem cells hold great potential as models of brain diseases. Stem cells can proliferate and can be banked, stored, and thawed for genomic, proteomic, and functional studies. Patient-derived, induced pluripotent stem cells and adult stem cells from the olfactory organ in the nose are already giving novel insights into a number of brain diseases, including Parkinson's disease and schizophrenia. Biomarker discovery may be possible from investigating disease-associated cell biologies in patient-derived stem cells.
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    Journal Title
    International Review of Neurobiology
    Volume
    101
    DOI
    https://doi.org/10.1016/B978-0-12-387718-5.00009-2
    Subject
    Neurosciences
    Psychology
    Cognitive Sciences
    Publication URI
    http://hdl.handle.net/10072/42716
    Collection
    • Journal articles

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