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dc.contributor.authorH. Soomro, Zahiden_US
dc.contributor.authorCecioni, Samyen_US
dc.contributor.authorBlanchard, Helenen_US
dc.contributor.authorPraly, Jean-Pierreen_US
dc.contributor.authorImberty, Anneen_US
dc.contributor.authorVidal, Sebastienen_US
dc.contributor.authorE. Matthews, Susanen_US
dc.date.accessioned2017-05-03T14:15:05Z
dc.date.available2017-05-03T14:15:05Z
dc.date.issued2011en_US
dc.date.modified2012-02-16T05:26:25Z
dc.identifier.issn1477-0520en_US
dc.identifier.doi10.1039/c1ob05676jen_US
dc.identifier.urihttp://hdl.handle.net/10072/42745
dc.description.abstractSynthetic multivalent glycoclusters show promise as anti-adhesives for the treatment of bacterial infections. Here we report the synthesis of a family of tetravalent galactose and lactose functionalised macrocycles based on the resorcin[4]arene core. The development of diastereoselective synthetic routes for the formation of lower-rim propargylated resorcin[4]arenes and their functionalistion via Cu-catalyzed azide-alkyne click chemistry is described. ELLA binding studies confirm that galactose sugar clusters are effective ligands for the PA-IL bacterial lectin of Pseudomonas aeruginosa while poor binding for the lactose-based monovalent probe and no binding could be measured for the multivalent glycoclusters was observed for the human galectin-1.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom6587en_US
dc.relation.ispartofpageto6597en_US
dc.relation.ispartofjournalOrganic & Biomolecular Chemistryen_US
dc.relation.ispartofvolume9en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBiologically Active Moleculesen_US
dc.subject.fieldofresearchcode030401en_US
dc.titleCuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectinsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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