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dc.contributor.authorBerners-Price, Sueen_US
dc.contributor.authorFilipovska, Aleksandraen_US
dc.date.accessioned2017-04-24T08:48:29Z
dc.date.available2017-04-24T08:48:29Z
dc.date.issued2011en_US
dc.date.modified2012-02-16T05:35:22Z
dc.identifier.issn17565901en_US
dc.identifier.doi10.1039/c1mt00062den_US
dc.identifier.urihttp://hdl.handle.net/10072/42797
dc.description.abstractThe application of gold in medicine is traceable for several thousand years and Au(I) compounds have been used clinically to treat rheumatoid arthritis since the last century. Recently research into gold-based drugs for a range of human diseases has seen a renaissance. Old as well as new Au(I) and Au(III) compounds have been used and designed with an aim of targeting cellular components that are implicated in the onset or progression of cancers, rheumatoid arthiritis, viral and parasitic diseases. In addition, new disease targets have been found for gold compounds that have given insight into the mechanism of action of these compounds, as well as in the molecular pathophysiology of human diseases. Here we discuss the rationale for the design and use of gold compounds that have specific and selective targets in cells to alleviate the symptoms of a range of human diseases. We summarise the most recent findings in this research and our own discoveries to show that gold compounds can be developed to become versatile and powerful drugs for diseases caused by dysfunction of selenol and thiol containing proteins.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherRoyal Society of Chemistryen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom863en_US
dc.relation.ispartofpageto873en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalMetallomicsen_US
dc.relation.ispartofvolume3en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBioinorganic Chemistryen_US
dc.subject.fieldofresearchcode030201en_US
dc.titleGold compounds as therapeutic agents for human diseasesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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