Mono- and 1,1'-Disubstituted Organoruthenium Cyclopentadiene Complexes: Synthesis, Structural Characterization, and Antitumoral Evaluation
Author(s)
Micallef, Leanne S
Loughrey, Bradley T
Healy, Peter C
Parsons, Peter G
Williams, Michael L
Griffith University Author(s)
Year published
2011
Metadata
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This article outlines the synthesis and characterization of a structurally diverse range of mono- and 1,10-disubstituted ruthenocenyl complexes. Compounds were prepared through organic manipulation of ruthenocenefluorocarbonyl and carboxylic acid functional groups and via the Friedel-Crafts acylation of ruthenocene. A dimetalated acid anhydride of the formula [Ru(?5-C5H5)(?5-C5H4-CO)]2O was also prepared, and the X-ray structure of this molecule is reported. Complexes were evaluated for their antiproliferative properties against a range of tumorigenic cell lines and a control human fibroblast, with results indicating these ...
View more >This article outlines the synthesis and characterization of a structurally diverse range of mono- and 1,10-disubstituted ruthenocenyl complexes. Compounds were prepared through organic manipulation of ruthenocenefluorocarbonyl and carboxylic acid functional groups and via the Friedel-Crafts acylation of ruthenocene. A dimetalated acid anhydride of the formula [Ru(?5-C5H5)(?5-C5H4-CO)]2O was also prepared, and the X-ray structure of this molecule is reported. Complexes were evaluated for their antiproliferative properties against a range of tumorigenic cell lines and a control human fibroblast, with results indicating these organoruthenium metallocenes to possess moderate to weak cytotoxicity toward cancerous cells.
View less >
View more >This article outlines the synthesis and characterization of a structurally diverse range of mono- and 1,10-disubstituted ruthenocenyl complexes. Compounds were prepared through organic manipulation of ruthenocenefluorocarbonyl and carboxylic acid functional groups and via the Friedel-Crafts acylation of ruthenocene. A dimetalated acid anhydride of the formula [Ru(?5-C5H5)(?5-C5H4-CO)]2O was also prepared, and the X-ray structure of this molecule is reported. Complexes were evaluated for their antiproliferative properties against a range of tumorigenic cell lines and a control human fibroblast, with results indicating these organoruthenium metallocenes to possess moderate to weak cytotoxicity toward cancerous cells.
View less >
Journal Title
Organometallics
Volume
30
Issue
6
Copyright Statement
Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
Subject
Inorganic chemistry
Biologically active molecules
Organic chemistry
Other chemical sciences
Organometallic chemistry