dc.contributor.author | Hegde, Vinayak | |
dc.contributor.author | Campitelli, Marc | |
dc.contributor.author | Quinn, Ronald J | |
dc.contributor.author | Camp, David | |
dc.date.accessioned | 2017-05-03T11:30:47Z | |
dc.date.available | 2017-05-03T11:30:47Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2012-06-29T05:49:21Z | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.doi | 10.1039/C1OB05299C | |
dc.identifier.uri | http://hdl.handle.net/10072/42817 | |
dc.description.abstract | A novel harringtonolide-inspired scaffold containing a cycloheptatriene ring and two fused cyclopentane rings has been synthesised from simple starting materials. The scaffold, containing a similar substitution pattern and relative stereochemistry to the complex diterpenoid, has been enumerated into a small library of derivatives. One of these library members has been converted into a sub-library of substituted triazoles using copper-catalysed azide-alkyne cycloaddition (click) chemistry. The scaffold may be useful in drug discovery or in the preparation of additional molecular probes for chemical biology. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 266112 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Royal Society of Chemistry | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 4570 | |
dc.relation.ispartofpageto | 4579 | |
dc.relation.ispartofissue | 12 | |
dc.relation.ispartofjournal | Organic & Biomolecular Chemistry | |
dc.relation.ispartofvolume | 9 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Organic chemical synthesis | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 340499 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 340503 | |
dc.title | Synthesis of novel molecular probes inspired by harringtonolide | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Sciences, Griffith Institute for Drug Discovery | |
gro.rights.copyright | © 2011 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version. | |
gro.date.issued | 2011 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Quinn, Ronald J. | |