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  • Recent Advances in β-Strand Mimetics

    Author(s)
    Loughlin, WA
    Fairlie, DP
    Griffith University Author(s)
    Loughlin, Wendy A.
    Year published
    2011
    Metadata
    Show full item record
    Abstract
    The extended peptide ߭strand has been recognized as a common recognition motif for certain classes of biomolecular receptors. Chemically constraining molecules to adopt a ߭strand conformation can substantially increase affinity for receptors that recognize ߭strands or ߭sheets. Many potential ߭strand mimetics have not yet been recognized as such, and include a diverse array of rigid scaffolds and privileged structures, a few classes being surveyed in this update of the current literature on ߭strand mimetics.The extended peptide ߭strand has been recognized as a common recognition motif for certain classes of biomolecular receptors. Chemically constraining molecules to adopt a ߭strand conformation can substantially increase affinity for receptors that recognize ߭strands or ߭sheets. Many potential ߭strand mimetics have not yet been recognized as such, and include a diverse array of rigid scaffolds and privileged structures, a few classes being surveyed in this update of the current literature on ߭strand mimetics.
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    Book Title
    Amino Acids, Peptides and Proteins in Organic Chemistry
    Volume
    4
    DOI
    https://doi.org/10.1002/9783527631827.ch3
    Subject
    Organic chemistry not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/43024
    Collection
    • Book chapters

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