Recent Advances in β-Strand Mimetics

Abstract

The extended peptide ߭strand has been recognized as a common recognition motif for certain classes of biomolecular receptors. Chemically constraining molecules to adopt a ߭strand conformation can substantially increase affinity for receptors that recognize ߭strands or ߭sheets. Many potential ߭strand mimetics have not yet been recognized as such, and include a diverse array of rigid scaffolds and privileged structures, a few classes being surveyed in this update of the current literature on ߭strand mimetics.