Recent Advances in β-Strand Mimetics
Author(s)
Loughlin, WA
Fairlie, DP
Griffith University Author(s)
Year published
2011
Metadata
Show full item recordAbstract
The extended peptide ߭strand has been recognized as a common recognition motif for certain classes of biomolecular receptors. Chemically constraining molecules to adopt a ߭strand conformation can substantially increase affinity for receptors that recognize ߭strands or ߭sheets. Many potential ߭strand mimetics have not yet been recognized as such, and include a diverse array of rigid scaffolds and privileged structures, a few classes being surveyed in this update of the current literature on ߭strand mimetics.The extended peptide ߭strand has been recognized as a common recognition motif for certain classes of biomolecular receptors. Chemically constraining molecules to adopt a ߭strand conformation can substantially increase affinity for receptors that recognize ߭strands or ߭sheets. Many potential ߭strand mimetics have not yet been recognized as such, and include a diverse array of rigid scaffolds and privileged structures, a few classes being surveyed in this update of the current literature on ߭strand mimetics.
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Book Title
Amino Acids, Peptides and Proteins in Organic Chemistry
Volume
4
Subject
Organic chemistry not elsewhere classified