Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives
Author(s)
Devakaram, Ruth
Black, David StC
Andrews, Katherine T
Fisher, Gillian M
Davis, Rohan A
Kumar, Naresh
Year published
2011
Metadata
Show full item recordAbstract
7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC50 values ranging between 1.9 and 3.9 μM.7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC50 values ranging between 1.9 and 3.9 μM.
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Journal Title
Bioorganic & Medicinal Chemistry
Volume
19
Issue
17
Subject
Infectious Agents
Medicinal and Biomolecular Chemistry
Organic Chemistry
Pharmacology and Pharmaceutical Sciences