Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives
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Author(s)
Devakaram, Ruth
Black, David StC
Andrews, Katherine T
Fisher, Gillian M
Davis, Rohan A
Kumar, Naresh
Year published
2011
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7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC50 values ranging between 1.9 and 3.9 μM.7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC50 values ranging between 1.9 and 3.9 μM.
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Journal Title
Bioorganic & Medicinal Chemistry
Volume
19
Issue
17
Copyright Statement
© 2011 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Infectious agents
Pharmacology and pharmaceutical sciences
Biochemistry and cell biology