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  • Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives

    Author(s)
    Devakaram, Ruth
    Black, David StC
    Andrews, Katherine T
    Fisher, Gillian M
    Davis, Rohan A
    Kumar, Naresh
    Griffith University Author(s)
    Andrews, Katherine T.
    Davis, Rohan A.
    Fisher, Gill M.
    Year published
    2011
    Metadata
    Show full item record
    Abstract
    7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC50 values ranging between 1.9 and 3.9 μM.7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC50 values ranging between 1.9 and 3.9 μM.
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    Journal Title
    Bioorganic & Medicinal Chemistry
    Volume
    19
    Issue
    17
    DOI
    https://doi.org/10.1016/j.bmc.2011.07.009
    Subject
    Infectious Agents
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/43207
    Collection
    • Journal articles

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