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dc.contributor.authorSimmonds, Michael J
dc.contributor.authorTripette, Julien
dc.contributor.authorSabapathy, Surendran
dc.contributor.authorMarshall-Gradisnik, Sonya M
dc.contributor.authorConnes, Philippe
dc.date.accessioned2017-10-30T12:31:00Z
dc.date.available2017-10-30T12:31:00Z
dc.date.issued2011
dc.identifier.issn1386-0291
dc.identifier.doi10.3233/CH-2011-1473
dc.identifier.urihttp://hdl.handle.net/10072/43268
dc.description.abstractBackground: The principal determinants of oxygen uptake ( /VdotO2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in /VdotO2 and cardiac output ( /Qdotc), or steady-state arteriovenous oxygen difference (a-vO2D) during submaximal cycling. Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ᠱ.3 yr; body mass index: 22.7 ᠲ.0 kg筭2), before each subject cycled at 105% of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state /VdotO2 during exercise and the a-vO2D at rest (r = -0.73, p < 0.05), and positively correlated to /Qdotc at rest (r = 0.71, p < 0.05). Blood viscosity at various shear rates was negatively correlated with the time constant of /VdotO2 (all p < 0.01) on-transient kinetics. Red blood cell deformability at various shear stress was positively correlated to the time constant of /VdotO2 (all p < 0.05) on-transient kinetics. Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIOS Press
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom231
dc.relation.ispartofpageto241
dc.relation.ispartofissue1-4
dc.relation.ispartofjournalClinical Hemorheology and Microcirculation
dc.relation.ispartofvolume49
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchExercise physiology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode420702
dc.titleCardiovascular dynamics during exercise are related to blood rheology
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-02-06T01:36:18Z
gro.hasfulltextNo Full Text
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorSimmonds, Michael J.


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