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dc.contributor.authorJ. Simmonds, Michaelen_US
dc.contributor.authorTripette, Julienen_US
dc.contributor.authorSabapathy, Surendranen_US
dc.contributor.authorM. Marshall-Gradisnik, Sonyaen_US
dc.contributor.authorConnes, Philippeen_US
dc.date.accessioned2017-05-03T13:17:44Z
dc.date.available2017-05-03T13:17:44Z
dc.date.issued2011en_US
dc.identifier.issn13860291en_US
dc.identifier.doi10.3233/CH-2011-1473en_US
dc.identifier.urihttp://hdl.handle.net/10072/43268
dc.description.abstractBackground: The principal determinants of oxygen uptake ( /VdotO2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in /VdotO2 and cardiac output ( /Qdotc), or steady-state arteriovenous oxygen difference (a-vO2D) during submaximal cycling. Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ᠱ.3 yr; body mass index: 22.7 ᠲ.0 kg筭2), before each subject cycled at 105% of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state /VdotO2 during exercise and the a-vO2D at rest (r = -0.73, p < 0.05), and positively correlated to /Qdotc at rest (r = 0.71, p < 0.05). Blood viscosity at various shear rates was negatively correlated with the time constant of /VdotO2 (all p < 0.01) on-transient kinetics. Red blood cell deformability at various shear stress was positively correlated to the time constant of /VdotO2 (all p < 0.05) on-transient kinetics. Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherIOS Pressen_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom231en_US
dc.relation.ispartofpageto241en_US
dc.relation.ispartofissue1-4en_US
dc.relation.ispartofjournalClinical Hemorheology and Microcirculationen_US
dc.relation.ispartofvolume49en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchExercise Physiologyen_US
dc.subject.fieldofresearchcode110602en_US
dc.titleCardiovascular dynamics during exercise are related to blood rheologyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-02-06T01:36:18Z
gro.hasfulltextNo Full Text


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