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dc.contributor.authorSerre, Kevinen_US
dc.contributor.authorSimmonds, Michaelen_US
dc.contributor.authorSabapathy, Surendranen_US
dc.contributor.authorMinahan, Clareen_US
dc.contributor.authorC. Gass, Gregoryen_US
dc.date.accessioned2017-04-24T10:25:23Z
dc.date.available2017-04-24T10:25:23Z
dc.date.issued2011en_US
dc.date.modified2012-05-15T22:25:56Z
dc.identifier.issn21611017en_US
dc.identifier.doihttp://www.omicsonline.org/ArchiveEMS/articleinpressEMS.phpen_US
dc.identifier.urihttp://hdl.handle.net/10072/43269
dc.description.abstractAims/hypothesis: Basal plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous, competitive inhibitor of nitric oxide synthase, is elevated in patients with type 2 diabetes. ADMA may contribute to the endothelial dysfunction and associated vascular complications observed in individuals with type 2 diabetes. The present study investigated the effect of 12 weeks of supervised walking exercise on plasma ADMA concentration in women aged 65-74 years with type 2 diabetes. Materials and methods: Fourteen women (aged 69 ᠳ yrs) with uncomplicated type 2 diabetes, completed 12 weeks of supervised, moderate-intensity walking at an intensity equivalent to their individual gas-exchange threshold. Blood was sampled for ADMA concentration before and after a 6-week intervention-free control period, and again after 6 and 12 weeks of exercise training. Results: Plasma ADMA concentration was found to be significantly lower after 12-weeks of exercise training when compared with baseline (0 wk) measurements. These results were accompanied by significant increases in time to exhaustion, relative and absolute peak oxygen uptake, and oxygen uptake at gas-exchange threshold. Conclusion/interpretation: Regular, moderate-intensity exercise decreases circulating ADMA concentrations in older women with type 2 diabetes. These results suggest that ADMA may play a role in the training-induced reduction in cardiovascular disease risk seen with exercise training in individuals with type 2 Diabetes.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent1053509 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherOmics Publishing Groupen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://omicsonline.org/emshome.phpen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom001-1en_US
dc.relation.ispartofpageto001-5en_US
dc.relation.ispartofjournalEndocrinology & Metabolic Syndromeen_US
dc.relation.ispartofvolumeS5en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchExercise Physiologyen_US
dc.subject.fieldofresearchSystems Physiologyen_US
dc.subject.fieldofresearchcode110602en_US
dc.subject.fieldofresearchcode111603en_US
dc.titleRapid Communication - Effect of Exercise Training on Asymmetric Dimethylarginine Concentration in Women Aged 65-74 years with Type 2 Diabetesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright remains with the authors 2011 The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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