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  • Comparative pharmacokinetics and pharmacodynamics of tablet, suspension and paste formulations of atenolol in cats

    Author(s)
    Khor, K.
    Campbell, F.
    Charles, B.
    Norris, Ross
    Greer, R.
    Rathbone, Michael
    Mills, P.
    Griffith University Author(s)
    Norris, Ross LG.
    Rathbone, Michael
    Year published
    2012
    Metadata
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    Abstract
    This study compared the pharmacokinetic and pharmacodynamic profiles of an extemporaneously prepared (compounded) atenolol paste and suspension for oral administration, against the commercially available divided tablet in healthy cats. Eleven healthy cats (mean: age 4 ᠰ.4 year, weight 5.0 ᠰ.7 kg) were dosed twice-daily with 12.5 mg atenolol (tablet, paste or suspension) for 7 days in a randomized cross-over design with a 7-day wash-out period. On day 7, an electrocardiogram was performed before and immediately after stress provocation (jugular venipuncture) at prestudy screening, and at 2, 6 and 12 h after morning dosing. ...
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    This study compared the pharmacokinetic and pharmacodynamic profiles of an extemporaneously prepared (compounded) atenolol paste and suspension for oral administration, against the commercially available divided tablet in healthy cats. Eleven healthy cats (mean: age 4 ᠰ.4 year, weight 5.0 ᠰ.7 kg) were dosed twice-daily with 12.5 mg atenolol (tablet, paste or suspension) for 7 days in a randomized cross-over design with a 7-day wash-out period. On day 7, an electrocardiogram was performed before and immediately after stress provocation (jugular venipuncture) at prestudy screening, and at 2, 6 and 12 h after morning dosing. Systolic arterial blood pressure (BP) was assessed following the second electrocardiogram. Plasma was collected at prestudy screening, and at 1, 2, 6 and 12 h to measure atenolol plasma concentrations. Mean atenolol dose was 2.5 mg/kg (range: 2.1-3.3 mg/kg). Stress-induced rise in heart rate was attenuated (P < 0.05) at every time point compared to baseline for all formulations. Although the paste significantly attenuated stress-induced elevation in heart rate at all time points, the effect was not consistently equivalent to the tablet. The BP was not altered (P > 0.05) at any time point by any formulation. In conclusion, there were no significant differences (P > 0.05) in any of the pharmacokinetic parameters or pharmacodynamic profiles of the paste and suspension compared to the commercially available tablet.
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    Journal Title
    Journal of Veterinary Pharmacology and Therapeutics
    Volume
    35
    Issue
    5
    DOI
    https://doi.org/10.1111/j.1365-2885.2011.01342.x
    Subject
    Veterinary sciences
    Pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/43428
    Collection
    • Journal articles

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