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dc.contributor.authorRulli, Nestoren_US
dc.contributor.authorRolph, Michaelen_US
dc.contributor.authorSrikiatkhachorn, Anonen_US
dc.contributor.authorAnantapreecha, Surapeeen_US
dc.contributor.authorGuglielmotti, Angeloen_US
dc.contributor.authorMahalingam, Sureshen_US
dc.date.accessioned2017-05-03T13:12:18Z
dc.date.available2017-05-03T13:12:18Z
dc.date.issued2011en_US
dc.date.modified2012-03-08T22:39:31Z
dc.identifier.issn00221899en_US
dc.identifier.doi10.1093/infdis/jir470en_US
dc.identifier.urihttp://hdl.handle.net/10072/43457
dc.description.abstractChikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-a, interferon-?, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infected mice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1026en_US
dc.relation.ispartofpageto1030en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalThe Journal of Infectious Diseasesen_US
dc.relation.ispartofvolume204en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Virologyen_US
dc.subject.fieldofresearchcode110804en_US
dc.titleProtection From Arthritis and Myositis in a Mouse Model of Acute Chikungunya Virus Disease by Bindarit, an Inhibitor of Monocyte Chemotactic Protein-1 Synthesisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, School of Natural Sciencesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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