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dc.contributor.authorSutherland, Greg T
dc.contributor.authorSiebert, Gerhard A
dc.contributor.authorKril, Jillian J
dc.contributor.authorMellick, George D
dc.date.accessioned2017-05-03T16:08:51Z
dc.date.available2017-05-03T16:08:51Z
dc.date.issued2011
dc.date.modified2012-03-09T05:39:33Z
dc.identifier.issn1387-2877
dc.identifier.doi10.3233/JAD-2011-110026
dc.identifier.urihttp://hdl.handle.net/10072/43508
dc.description.abstractAlzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative disorders. Why some individuals develop one disease rather than the other is not clear. Association studies with a case-control design are the time-honored approach to identifying risk factors. Extensive association studies have been carried out in both diseases creating a large knowledge database, however, reproducible risk factors remain rare. This general lack of knowledge of pathogenesis prevents us from reducing the worldwide burden of these diseases. Case-control studies are reductionist paradigms that assume, for maximum power, that the two populations being compared are exclusive and homogenous. The common occurrence of incidental AD and PD-type pathology combined with 'intermediate phenotypes' such as dementia with Lewy bodies suggest that aging itself, AD, and PD are part of a complex continuum characterized by variable amounts of amyloid-߬ tau, and a-synuclein pathology. This heterogeneity may be a contributor to the lack of reproducibility in association studies to date. Here, we speculate on alternative experimental approaches to the case-control paradigm and consider how the association-study literature for AD and PD might be re-interpreted in terms of a disease spectrum.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIOS Press
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom395
dc.relation.ispartofpageto415
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Alzheimer's Disease
dc.relation.ispartofvolume25
dc.rights.retentionY
dc.subject.fieldofresearchNeurology and Neuromuscular Diseases
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110904
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.titleKnowing Me, Knowing You: Can a Knowledge of Risk Factors for Alzheimer's Disease Prove Useful in Understanding the Pathogenesis of Parkinson's Disease?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George
gro.griffith.authorSiebert, Gerhard
gro.griffith.authorSutherland, Greg T.


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