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dc.contributor.authorBoschen, Mark J
dc.date.accessioned2017-05-03T14:37:57Z
dc.date.available2017-05-03T14:37:57Z
dc.date.issued2011
dc.date.modified2012-03-09T05:55:03Z
dc.identifier.issn0706-7437
dc.identifier.urihttp://hdl.handle.net/10072/43529
dc.description.abstractOBJECTIVE: Generalized anxiety disorder (GAD) is a chronic anxiety disorder that leads to significant functional impairment and reduced quality of life. Pregabalin is a novel analogue of the inhibitory neurotransmitter gamma amino butyric acid, which has been proposed as a treatment for a range of conditions including GAD. This study examined the efficacy of pregabalin for GAD across published trials, using a meta-analytic method. METHOD: This study examined the 7 published placebo-controlled trials of GAD using pregabalin, and, using meta-analytic techniques, we calculated the effect size of treatment with pregabalin (compared with placebo) on a total of 1352 people. RESULTS: The overall effect size of pregabalin in the treatment of GAD was Hedges' g = 0.364, with an effect size of 0.349 on psychic anxiety symptoms and of 0.239 on somatic anxiety symptoms CONCLUSION: Pregabalin is an efficacious therapy for GAD, although effect sizes are smaller than those from earlier studies. Limitations and future research directions are discussed.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCanadian Psychiatric Association
dc.publisher.placeCanada
dc.publisher.urihttp://publications.cpa-apc.org/browse/documents/549
dc.publisher.urihttp://publications.cpa-apc.org/media.php?mid=1219
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom558
dc.relation.ispartofpageto566
dc.relation.ispartofissue9
dc.relation.ispartofjournalCanadian Journal of Psychiatry
dc.relation.ispartofvolume56
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.titleA meta-analysis of the efficacy of pregabalin in the treatment of generalized anxiety disorder
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Applied Psychology
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorBoschen, Mark J.


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