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dc.contributor.authorKidd, LJ
dc.contributor.authorCowling, NR
dc.contributor.authorWu, ACK
dc.contributor.authorKelly, WL
dc.contributor.authorForwood, MR
dc.date.accessioned2017-05-03T12:07:14Z
dc.date.available2017-05-03T12:07:14Z
dc.date.issued2011
dc.date.modified2012-03-20T22:31:50Z
dc.identifier.issn0736-0266
dc.identifier.doi10.1002/jor.21464
dc.identifier.urihttp://hdl.handle.net/10072/43666
dc.description.abstractBecause bisphosphonates (BPs) are potent inhibitors of bone resorption, we hypothesized that they would retard direct remodeling of stress fractures. The aim of this study was to determine the effect of risedronate on direct remodeling and woven bone callus formation following stress fracture formation in the rat ulna. In 135 adult female Wistar rats, cyclic loading of the ulna created stress fractures. Rats were treated daily with oral saline, or risedronate at 0.1 or 1.0 mg/kg. From each bone, histomorphometry was performed on sections stained with toluidine blue at a standard level along the fracture. The high dose of risedronate caused a significant decrease in the percentage of repaired stress fracture and bone resorption along the stress fracture line at 6 and 10 weeks after loading (p < 0.05). At this dose, intracortical resorption was significantly reduced at 10 weeks after loading and intracortical new bone area was significantly reduced at 6 and 10 weeks. Woven bone formation and consolidation phases of stress fracture repair were not affected by low or high doses of risedronate. In conclusion, high dose bisphosphonate treatment impaired healing of a large stress fracture line by reducing the volume of bone resorbed and replaced during remodeling. We also confirmed that periosteal callus formation was not adversely affected by risedronate treatment.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1827
dc.relation.ispartofpageto1833
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Orthopaedic Research
dc.relation.ispartofvolume29
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.titleBisphosphonate Treatment Delays Stress Fracture Remodeling in the Rat Ulna
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorForwood, Mark R.


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