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  • The medicinal potential of Scaevola spinescens: toxicity, antibacterial and antiviral activities

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    Author(s)
    Cock, Ian
    Kukkonen, L.
    Griffith University Author(s)
    Cock, Ian E.
    Year published
    2011
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    Abstract
    Introduction: S. spinescens (SS) (aka prickly fanflower, maroon bush) is an endemic Australian plant with a history of use as a medicinal agent by indigenous Australians. Yet the pharmacological bioactivities of this plant are poorly documented. Methods: Solvent extracts of SS were tested for antibacterial, antifungal and antiviral activities and toxicity in vitro. Results: All extracts displayed antibacterial activity in the disc diffusion assay. The methanol extract proved to have the broadest specificity, inhibiting the growth of 7 of the 14 bacteria tested (50 %). The water, ethyl acetate, chloroform and hexane ...
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    Introduction: S. spinescens (SS) (aka prickly fanflower, maroon bush) is an endemic Australian plant with a history of use as a medicinal agent by indigenous Australians. Yet the pharmacological bioactivities of this plant are poorly documented. Methods: Solvent extracts of SS were tested for antibacterial, antifungal and antiviral activities and toxicity in vitro. Results: All extracts displayed antibacterial activity in the disc diffusion assay. The methanol extract proved to have the broadest specificity, inhibiting the growth of 7 of the 14 bacteria tested (50 %). The water, ethyl acetate, chloroform and hexane extracts inhibited the growth of 6 (43%), 5 (36%), 5 (36%), and 4 (29%) of the 14 bacteria tested respectively. SS methanolic extracts were equally effective against Gram-positive (50 %) and Gram-negative bacteria (50 %). All other extracts were more effective at inhibiting the growth of Gram-negative bacteria. All extracts also displayed antiviral activity in the MS2 plaque reduction assay with the methanol, water, ethyl acetate, chloroform and hexane extracts inhibiting 95ᠱ.8 %, 72 ᠶ.3 %, 83 ᠴ.5 %, 100 ᠰ % and 48 ᠱ3 % of plaque formation respectively at a dose range of 0.6-3mg/ml. All SS extracts were non-toxic in the Artemia fransiscana bioassay with no significant increase in mortality induced by any extract at 24 and 48 h. The only increase in mortality was seen for the water extract after 72h at 2mg/ml, although even this extract displayed low toxicity, inducing only 42 ᠲ.3% mortality. Discussion: The lack of toxicity of the SS extracts and their inhibitory bioactivity against bacteria and viruses validate Australian Aboriginal usage of S. spinescens and indicates its medicinal potential.
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    Conference Title
    ASCEPT
    Publisher URI
    http://www.ascept.org/Past-Annual-Scientific-Meetings/2011.aspx
    Copyright Statement
    © The Author(s) 2011. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this conference please refer to the conference’s website or contact the authors.
    Subject
    Biological Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/43744
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    • Conference outputs

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    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander