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dc.contributor.authorMitragotri, Samir
dc.contributor.authorAnissimov, Yuri G
dc.contributor.authorBunge, Annette L
dc.contributor.authorFrasch, H Frederick
dc.contributor.authorGuy, Richard H
dc.contributor.authorHadgraft, Jonathan
dc.contributor.authorKasting, Gerald B
dc.contributor.authorLane, Majella E
dc.contributor.authorRoberts, Michael S
dc.date.accessioned2017-05-03T15:13:56Z
dc.date.available2017-05-03T15:13:56Z
dc.date.issued2011
dc.date.modified2012-03-21T23:01:01Z
dc.identifier.issn0378-5173
dc.identifier.doi10.1016/j.ijpharm.2011.02.023
dc.identifier.urihttp://hdl.handle.net/10072/43750
dc.description.abstractMathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed over the last several decades to yield predictions of skin permeability to various molecules. These efforts include the development of empirical approaches such as quantitative structure-permeability relationships and porous pathway theories as well as the establishment of rigorous structure-based models. In addition to establishing the necessary mathematical framework to describe these models, efforts have also been dedicated to determining the key parameters that are required to use these models. This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom115
dc.relation.ispartofpageto129
dc.relation.ispartofjournalInternational Journal of Pharmaceutics
dc.relation.ispartofvolume418
dc.rights.retentionY
dc.subject.fieldofresearchBiological mathematics
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmaceutical sciences
dc.subject.fieldofresearchcode490102
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321405
dc.titleMathematical models of skin permeability: An overview
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorAnissimov, Yuri G.


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