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dc.contributor.authorOwen, Suzzanneen_US
dc.contributor.authorRose'Meyer, Roselynen_US
dc.contributor.authorMassa, Helenen_US
dc.date.accessioned2017-04-24T11:57:04Z
dc.date.available2017-04-24T11:57:04Z
dc.date.issued2011en_US
dc.date.modified2012-03-21T23:05:15Z
dc.identifier.issn0024-3205en_US
dc.identifier.doi10.1016/j.lfs.2011.05.022en_US
dc.identifier.urihttp://hdl.handle.net/10072/43756
dc.description.abstractAims: Development of urinary incontinence, for many women, occurs following menopause. Dietary phytoestrogens consumed over the long term may affect the contractile function and maintenance of the urinary bladder in post menopausal women. This study examined the muscarinic receptor mediated contractile responses in the rat isolated bladder in response to ovariectomy and long term dietary phytoestrogen consumption. Main methods: Ovariectomised or sham-operated female Wistar rats (8 weeks) were fed either normal rat chow (soy, phytoestrogens) or a non-soy (phytoestrogen free) diet. Bladders were dissected from rats at 12, 24 and 52 weeks of age and placed in 25 ml organ baths filled with McEwans solution. Key findings: The contractile response to carbachol, in 12 week old female rats did not change as a result of dietary phytoestrogens or ovariectomy (PN0.05). At 24 weeks of age, detrusor muscle strip responses to carbachol from non-soy fed ovariectomised rats were attenuated (Pb0.05). At 52 weeks, bladder detrusor strip responses to carbachol were reduced in all treatment groups with the exception of the soy-fed sham operated rats. Significance: These results suggest an age-related reduction in the contractile response of the detrusor to the muscarinic receptor agonist carbachol, which may be prevented by long term dietary phytoestrogen intake.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom213en_US
dc.relation.ispartofpageto220en_US
dc.relation.ispartofissue7-8en_US
dc.relation.ispartofjournalLife Sciencesen_US
dc.relation.ispartofvolume89en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchReceptors and Membrane Biologyen_US
dc.subject.fieldofresearchcode060110en_US
dc.titleDietary phytoestrogens maintain contractile responses to carbachol with age in the female rat isolated bladderen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Nursing and Midwiferyen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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