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  • Olfactory ensheathing cells: how different subpopulations regulate axon guidance

    Author(s)
    St John, James
    Ekberg, Jenny
    Griffith University Author(s)
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2011
    Metadata
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    Abstract
    The glia of the olfactory system, olfactory ensheathing cells (OECs) are intimately associated with the axons of primary olfactory neurons that extend from the olfactory epithelium to their targets within the olfactory bulb. However, OECs are not a uniform population but instead there are different subpopulations each with a different molecular profile and proposed role in vivo. We have used OEC-axon assays and determined that OECs play an active role in modulating the growth of pioneer olfactory axons. The motility of OECs was mediated by GDNF, which stimulated cell migration and increased the apparent motility of the axons ...
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    The glia of the olfactory system, olfactory ensheathing cells (OECs) are intimately associated with the axons of primary olfactory neurons that extend from the olfactory epithelium to their targets within the olfactory bulb. However, OECs are not a uniform population but instead there are different subpopulations each with a different molecular profile and proposed role in vivo. We have used OEC-axon assays and determined that OECs play an active role in modulating the growth of pioneer olfactory axons. The motility of OECs was mediated by GDNF, which stimulated cell migration and increased the apparent motility of the axons whereas loss of OECs via laser ablation of the cells inhibited olfactory axon outgrowth. These results demonstrate that the migration of OECs strongly regulates the motility of axons and that stimulation of OEC motility enhances axon extension and growth cone activity. We then determined that axons respond differently to OECs derived from the peripheral region of the olfactory nerve or from the olfactory bulb. We purified OECs from anatomically distinct regions of the olfactory bulb and used cell behaviour assays to reveal that OECs from the olfactory bulb are a functionally heterogeneous population with distinct differences which are consistent with their proposed roles in vivo. These results demonstrate that OECs from the olfactory bulb are a heterogeneous population that use lamellipodial waves to regulate cell-cell recognition.
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    Conference Title
    Proceedings of the Australasian Association for Chemosensory Sciences annual meeting 2011
    Subject
    Central Nervous System
    Peripheral Nervous System
    Publication URI
    http://hdl.handle.net/10072/43811
    Collection
    • Conference outputs

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