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  • Evidence that a higher ATP cost of muscular contraction contributes to the lower mechanical efficiency associated with COPD: preliminary findings

    Author
    Haseler, Luke
    Year published
    2011
    Metadata
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    Abstract
    Impaired metabolism in peripheral skeletal muscles potentially contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). We used 31P-magnetic resonance spectroscopy (31P-MRS) to examine the energy cost and skeletal muscle energetics in six patients with COPD during dynamic plantar flexion exercise compared with six well-matched healthy control subjects. Patients with COPD displayed a higher energy cost of muscle contraction compared with the controls (control: 6.1 ᠳ.1% of rest筩n-1痭1, COPD: 13.6 ᠸ.3% of rest筩n-1痭1, P = 0.01). Although, the initial phosphocreatine resynthesis rate was also significantly ...
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    Impaired metabolism in peripheral skeletal muscles potentially contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). We used 31P-magnetic resonance spectroscopy (31P-MRS) to examine the energy cost and skeletal muscle energetics in six patients with COPD during dynamic plantar flexion exercise compared with six well-matched healthy control subjects. Patients with COPD displayed a higher energy cost of muscle contraction compared with the controls (control: 6.1 ᠳ.1% of rest筩n-1痭1, COPD: 13.6 ᠸ.3% of rest筩n-1痭1, P = 0.01). Although, the initial phosphocreatine resynthesis rate was also significantly attenuated in patients with COPD compared with controls (control: 74 ᠱ7% of rest/min, COPD: 52 ᠱ3% of rest/min, P = 0.04), when scaled to power output, oxidative ATP synthesis was similar between groups (6.5 ᠲ.3% of rest筩n-1痭1 in control and 7.8 ᠳ.9% of rest筩n-1痭1 in COPD, P = 0.52). Therefore, our results reveal, for the first time that in a small subset of patients with COPD a higher ATP cost of muscle contraction may substantially contribute to the lower mechanical efficiency previously reported in this population. In addition, it appears that some patients with COPD have preserved mitochondrial function and normal energy supply in lower limb skeletal muscle.
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    Journal Title
    American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
    Volume
    300
    Issue
    5
    DOI
    https://doi.org/10.1152/ajpregu.00835.2010
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Medical and Health Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/44074
    Collection
    • Journal articles

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