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dc.contributor.authorHaseler, Lukeen_US
dc.date.accessioned2017-05-03T14:56:31Z
dc.date.available2017-05-03T14:56:31Z
dc.date.issued2011en_US
dc.date.modified2012-03-29T04:53:01Z
dc.identifier.issn03636119en_US
dc.identifier.doi10.1152/ajpregu.00835.2010en_US
dc.identifier.urihttp://hdl.handle.net/10072/44074
dc.description.abstractImpaired metabolism in peripheral skeletal muscles potentially contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). We used 31P-magnetic resonance spectroscopy (31P-MRS) to examine the energy cost and skeletal muscle energetics in six patients with COPD during dynamic plantar flexion exercise compared with six well-matched healthy control subjects. Patients with COPD displayed a higher energy cost of muscle contraction compared with the controls (control: 6.1 ᠳ.1% of rest筩n-1痭1, COPD: 13.6 ᠸ.3% of rest筩n-1痭1, P = 0.01). Although, the initial phosphocreatine resynthesis rate was also significantly attenuated in patients with COPD compared with controls (control: 74 ᠱ7% of rest/min, COPD: 52 ᠱ3% of rest/min, P = 0.04), when scaled to power output, oxidative ATP synthesis was similar between groups (6.5 ᠲ.3% of rest筩n-1痭1 in control and 7.8 ᠳ.9% of rest筩n-1痭1 in COPD, P = 0.52). Therefore, our results reveal, for the first time that in a small subset of patients with COPD a higher ATP cost of muscle contraction may substantially contribute to the lower mechanical efficiency previously reported in this population. In addition, it appears that some patients with COPD have preserved mitochondrial function and normal energy supply in lower limb skeletal muscle.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherAmerican Physiological Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefromR1142en_US
dc.relation.ispartofpagetoR1147en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalAmerican Journal of Physiology: Regulatory, Integrative and Comparative Physiologyen_US
dc.relation.ispartofvolume300en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleEvidence that a higher ATP cost of muscular contraction contributes to the lower mechanical efficiency associated with COPD: preliminary findingsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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