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  • Development of Novel Drug Delivery Prototypes Devices for Targeted, Delivery Drug Therapy at the Molecular Level in Aqueous Media

    Author(s)
    George, Roy
    Oberholzer, Theunis Gerhardus
    Perchyonok, Victoria Tamara
    Griffith University Author(s)
    Oberholzer, Theunis
    George, Roy
    Perchyonok, Tamara
    Year published
    2011
    Metadata
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    Abstract
    Abstract: A novel approach in target specific molecular prototype drug delivery system concerns the attempt to employ radical affording substances (RAS) or radical quenching substances (RQS) as prodrugs able to produce irreversible damage on the desired target and therefore to stimulate cellular apoptosis. However, radical species generated can react quickly within the chemical environment prior to reaching its proper site of action. In this short communication, we report our investigations towards developing two alternative novel, simple, flexible and effective drug delivery systems that provide optimal dosage of drugs ...
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    Abstract: A novel approach in target specific molecular prototype drug delivery system concerns the attempt to employ radical affording substances (RAS) or radical quenching substances (RQS) as prodrugs able to produce irreversible damage on the desired target and therefore to stimulate cellular apoptosis. However, radical species generated can react quickly within the chemical environment prior to reaching its proper site of action. In this short communication, we report our investigations towards developing two alternative novel, simple, flexible and effective drug delivery systems that provide optimal dosage of drugs precisely where and when needed and therefore achieve and sustain a complex delivery profile. We have demonstrated the application of two effective molecular prototype delivery systems able to harness free radical reactivity within the laboratory where biological processes can be studied and controlled, leading to the prevention of disease and the development of new treatments for disease states mediated by free radicals.
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    Journal Title
    Current Drug Delivery
    Volume
    8
    Issue
    4
    DOI
    https://doi.org/10.2174/156720111796642237
    Subject
    Dental Therapeutics, Pharmacology and Toxicology
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/44120
    Collection
    • Journal articles

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