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dc.contributor.authorGeorge, Roy
dc.contributor.authorOberholzer, Theunis Gerhardus
dc.contributor.authorPerchyonok, Victoria Tamara
dc.date.accessioned2017-05-03T15:34:28Z
dc.date.available2017-05-03T15:34:28Z
dc.date.issued2011
dc.date.modified2012-04-01T22:44:40Z
dc.identifier.issn1567-2018
dc.identifier.doi10.2174/156720111796642237
dc.identifier.urihttp://hdl.handle.net/10072/44120
dc.description.abstractAbstract: A novel approach in target specific molecular prototype drug delivery system concerns the attempt to employ radical affording substances (RAS) or radical quenching substances (RQS) as prodrugs able to produce irreversible damage on the desired target and therefore to stimulate cellular apoptosis. However, radical species generated can react quickly within the chemical environment prior to reaching its proper site of action. In this short communication, we report our investigations towards developing two alternative novel, simple, flexible and effective drug delivery systems that provide optimal dosage of drugs precisely where and when needed and therefore achieve and sustain a complex delivery profile. We have demonstrated the application of two effective molecular prototype delivery systems able to harness free radical reactivity within the laboratory where biological processes can be studied and controlled, leading to the prevention of disease and the development of new treatments for disease states mediated by free radicals.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom582
dc.relation.ispartofpageto585
dc.relation.ispartofissue4
dc.relation.ispartofjournalCurrent Drug Delivery
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchDental therapeutics, pharmacology and toxicology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode320303
dc.subject.fieldofresearchcode3214
dc.titleDevelopment of Novel Drug Delivery Prototypes Devices for Targeted, Delivery Drug Therapy at the Molecular Level in Aqueous Media
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorGeorge, Roy


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