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dc.contributor.authorLiu, G
dc.contributor.authorFan, W
dc.contributor.authorMiao, X
dc.contributor.authorXiao, Y
dc.contributor.authorGood, D
dc.contributor.authorWei, MQ
dc.date.accessioned2017-05-03T13:12:22Z
dc.date.available2017-05-03T13:12:22Z
dc.date.issued2011
dc.date.modified2012-04-01T22:54:50Z
dc.identifier.issn1662-1018
dc.identifier.doi10.4028/www.scientific.net/JBBTE.11.81
dc.identifier.urihttp://hdl.handle.net/10072/44135
dc.description.abstractVascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMP-7) are key regulators of angiogenesis and osteogenesis during bone regeneration. The aim of this study was to investigate the possibility of realizing sequential release of the two growth factors using a novel composite scaffold. Poly(lactic-co-glycolic acid) (PLGA)-Akermanite (AK) microspheres were used to make the composite scaffold, which was then loaded with BMP-7, followed by embedding in a gelatin hydrogel matrix loaded with VEGF. The release profiles of the growth factors were studied and selected osteogenic related markers of bone marrow stromal cells (BMSCs) were analysed. It was shown that the composite scaffolds exhibited a fast initial burst release of VEGF within the first 3 days and a sustained slow release of BMP-7 over the full period of 20 days. The in vitro proliferation and differentiation of the BMSCs cultured in the osteogenic medium were enhanced by 1 to 2 times, resulting from the additionally and sequentially release of growth factors from the PLGA-AK/gelatin composite scaffolds.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherTrans Tech Publications Ltd.
dc.publisher.placeSwitzerland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom81
dc.relation.ispartofpageto91
dc.relation.ispartofissue81
dc.relation.ispartofjournalJournal of Biomimetics, Biomaterials, and Tissue Engineering
dc.relation.ispartofvolume11
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode40
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode321199
dc.subject.fieldofresearchcode4003
dc.titleSequential Release of BMP-7 and VEGF from the PLGA/AK-Gelatin Composite Scaffolds
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorWei, Ming Q.
gro.griffith.authorXiao, Yin


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