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dc.contributor.authorGood, Michael F
dc.date.accessioned2017-05-03T15:04:53Z
dc.date.available2017-05-03T15:04:53Z
dc.date.issued2011
dc.date.modified2012-04-03T22:44:55Z
dc.identifier.issn1471-4922
dc.identifier.doi10.1016/j.pt.2011.03.003
dc.identifier.urihttp://hdl.handle.net/10072/44188
dc.description.abstractNow, 27 years following the cloning of malaria antigens with the promise of the rapid development of a malaria vaccine, we face significant obstacles that are belatedly being addressed. Poor immunogenicity of subunit vaccine antigens and significant antigenic diversity of target epitopes represent major hurdles for which there are no clear strategies for a way forward within the current paradigm. Thus, a different paradigm - a vaccine that uses the whole organism - is now being examined. Although most advances in this approach relate to a vaccine for the pre-erythrocytic stages (sporozoites, liver stages), this opinion paper will outline the possibilities of developing a whole parasite vaccine for the blood stage and address some of the challenges for this strategy, which are entirely different to the challenges for a subunit vaccine. It is the view of the author that both vaccine paradigms should be pursued, but that success will come more quickly using the paranormal approach of exposing individuals to ultra-low doses of whole attenuated or killed parasites.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom335
dc.relation.ispartofpageto340
dc.relation.ispartofissue8
dc.relation.ispartofjournalTrends in Parasitology
dc.relation.ispartofvolume27
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchInfectious agents
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310702
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.titleA whole parasite vaccine to control the blood stages of Plasmodium - the case for lateral thinking
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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