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dc.contributor.authorGood, Michaelen_US
dc.date.accessioned2017-04-24T12:31:05Z
dc.date.available2017-04-24T12:31:05Z
dc.date.issued2011en_US
dc.date.modified2012-04-03T22:44:55Z
dc.identifier.issn1471-4922en_US
dc.identifier.doi10.1016/j.pt.2011.03.003en_US
dc.identifier.urihttp://hdl.handle.net/10072/44188
dc.description.abstractNow, 27 years following the cloning of malaria antigens with the promise of the rapid development of a malaria vaccine, we face significant obstacles that are belatedly being addressed. Poor immunogenicity of subunit vaccine antigens and significant antigenic diversity of target epitopes represent major hurdles for which there are no clear strategies for a way forward within the current paradigm. Thus, a different paradigm - a vaccine that uses the whole organism - is now being examined. Although most advances in this approach relate to a vaccine for the pre-erythrocytic stages (sporozoites, liver stages), this opinion paper will outline the possibilities of developing a whole parasite vaccine for the blood stage and address some of the challenges for this strategy, which are entirely different to the challenges for a subunit vaccine. It is the view of the author that both vaccine paradigms should be pursued, but that success will come more quickly using the paranormal approach of exposing individuals to ultra-low doses of whole attenuated or killed parasites.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom335en_US
dc.relation.ispartofpageto340en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalTrends in Parasitologyen_US
dc.relation.ispartofvolume27en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleA whole parasite vaccine to control the blood stages of Plasmodium - the case for lateral thinkingen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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