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dc.contributor.authorGalvao, Daniel A
dc.contributor.authorTaaffe, Dennis R
dc.contributor.authorCormie, Prue
dc.contributor.authorSpry, Nigel
dc.contributor.authorChambers, Suzanne K
dc.contributor.authorPeddle-McIntyre, Carolyn
dc.contributor.authorBaker, Michael
dc.contributor.authorDenham, James
dc.contributor.authorJoseph, David
dc.contributor.authorGroom, Geoff
dc.contributor.authorNewton, Robert U
dc.date.accessioned2017-05-03T14:37:09Z
dc.date.available2017-05-03T14:37:09Z
dc.date.issued2011
dc.date.modified2012-04-03T22:51:58Z
dc.identifier.issn1471-2407
dc.identifier.doi10.1186/1471-2407-11-517
dc.identifier.urihttp://hdl.handle.net/10072/44198
dc.description.abstractBackground The presence of bone metastases has excluded participation of prostate cancer patients in exercise intervention studies to date and is also a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. However, this group of patients often have developed significant muscle atrophy and functional impairments from prior and continuing androgen deprivation that is exacerbated by subsequent and more intensive interventions such as chemotherapy. The aim of this study is to determine the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. Methods/Design Multi-site randomized controlled trial in Western Australia and New South Wales to examine the efficacy and safety of a modular multi-modal physical exercise program in 90 prostate cancer survivors with bone metastases. Participants will be randomized to (1) modular multi-modal exercise intervention group or (2) usual medical care group. The modular multi-modal exercise group will receive a 3-month supervised exercise program based on bone lesion location/extent. Measurements for primary and secondary endpoints will take place at baseline, 3 months (end of the intervention) and 6 months follow-up. Discussion Delaying or preventing skeletal complication and improving physical function for men with bone metastases would provide clinically meaningful benefits to patients. However, exercise programs must be designed and executed with careful consideration of the skeletal complications associated with bone metastatic disease and cumulative toxicities from androgen deprivation such as osteoporosis and increased risk of fractures. The results from this study will form the basis for the development of a specific exercise prescription in this patient group in order to alleviate disease burden, counteract the adverse treatment related side-effects and enhance quality of life.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent243484 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom517-1
dc.relation.ispartofpageto517-7
dc.relation.ispartofjournalBMC Cancer
dc.relation.ispartofvolume11
dc.rights.retentionY
dc.subject.fieldofresearchSports science and exercise not elsewhere classified
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode420799
dc.subject.fieldofresearchcode3211
dc.titleEfficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: A randomized controlled trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.rights.copyright© 2011 Galvão et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorChambers, Suzanne K.


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