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dc.contributor.authorBaker, Michaelen_US
dc.contributor.authorChambers, Suzanneen_US
dc.contributor.authorCormie, Prueen_US
dc.contributor.authorDenham, Jamesen_US
dc.contributor.authorGalvão, Danielen_US
dc.contributor.authorGroom, Geoffen_US
dc.contributor.authorJoseph, Daviden_US
dc.contributor.authorNewton, Roberten_US
dc.contributor.authorPeddle-McIntyre, Carolynen_US
dc.contributor.authorSpry, Nigelen_US
dc.contributor.authorTaaffe, Dennisen_US
dc.date.accessioned2017-04-04T20:02:35Z
dc.date.available2017-04-04T20:02:35Z
dc.date.issued2011en_US
dc.date.modified2012-04-03T22:51:58Z
dc.identifier.issn1471-2407en_US
dc.identifier.doi10.1186/1471-2407-11-517en_US
dc.identifier.urihttp://hdl.handle.net/10072/44198
dc.description.abstractBackground The presence of bone metastases has excluded participation of prostate cancer patients in exercise intervention studies to date and is also a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. However, this group of patients often have developed significant muscle atrophy and functional impairments from prior and continuing androgen deprivation that is exacerbated by subsequent and more intensive interventions such as chemotherapy. The aim of this study is to determine the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. Methods/Design Multi-site randomized controlled trial in Western Australia and New South Wales to examine the efficacy and safety of a modular multi-modal physical exercise program in 90 prostate cancer survivors with bone metastases. Participants will be randomized to (1) modular multi-modal exercise intervention group or (2) usual medical care group. The modular multi-modal exercise group will receive a 3-month supervised exercise program based on bone lesion location/extent. Measurements for primary and secondary endpoints will take place at baseline, 3 months (end of the intervention) and 6 months follow-up. Discussion Delaying or preventing skeletal complication and improving physical function for men with bone metastases would provide clinically meaningful benefits to patients. However, exercise programs must be designed and executed with careful consideration of the skeletal complications associated with bone metastatic disease and cumulative toxicities from androgen deprivation such as osteoporosis and increased risk of fractures. The results from this study will form the basis for the development of a specific exercise prescription in this patient group in order to alleviate disease burden, counteract the adverse treatment related side-effects and enhance quality of life.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent243484 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherBioMed Centralen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom517-1en_US
dc.relation.ispartofpageto517-7en_US
dc.relation.ispartofjournalBMC Canceren_US
dc.relation.ispartofvolume11en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchHuman Movement and Sports Science not elsewhere classifieden_US
dc.subject.fieldofresearchcode110699en_US
dc.titleEfficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: A randomized controlled trialen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2011, http://dx.doi.org/10.1186/1471-2407-11-517 et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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