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dc.contributor.authorGood, Michaelen_US
dc.date.accessioned2017-05-03T15:04:59Z
dc.date.available2017-05-03T15:04:59Z
dc.date.issued2011en_US
dc.date.modified2012-04-09T23:09:37Z
dc.identifier.issn1420-682Xen_US
dc.identifier.doi10.1007/s00018-011-0634-5en_US
dc.identifier.urihttp://hdl.handle.net/10072/44307
dc.description.abstractMalaria presents a challenge to world health that to date has been beyond the abilities of researchers to conquer. This critique presents some of the strategies employed by the parasite to overcome immunity and the immunological challenges that we face to develop vaccines. A conclusion is that a vaccine must identify novel antigens or epitopes that are not normally immunogenic and which are therefore not under immune pressure and most likely to be conserved between different strains. Such antigens are most likely to be targets of cellular immunity. The case for a whole parasite blood stage vaccine is presented based on these premises.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherSpringeren_US
dc.publisher.placeSwitzerlanden_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1105en_US
dc.relation.ispartofpageto1113en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalCellular and Molecular Life Sciencesen_US
dc.relation.ispartofvolume68en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleOur impasse in developing a malaria vaccineen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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