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dc.contributor.authorMuhammad, Faheem
dc.contributor.authorGuo, Mingyi
dc.contributor.authorGuo, Yingjie
dc.contributor.authorQi, Wenxiu
dc.contributor.authorQu, Fengyu
dc.contributor.authorSun, Fuxing
dc.contributor.authorZhao, Huijun
dc.contributor.authorZhu, Guangshan
dc.date.accessioned2017-05-03T16:04:09Z
dc.date.available2017-05-03T16:04:09Z
dc.date.issued2011
dc.date.modified2012-04-10T22:56:40Z
dc.identifier.issn0959-9428
dc.identifier.doi10.1039/C1JM12119G
dc.identifier.urihttp://hdl.handle.net/10072/44382
dc.description.abstractEfficacious chemotherapy mainly hinges on the tumor-specific delivery of anticancer drugs. Herein we report a successful fabrication of highly photoluminescent and water dispersible ZnO quantum dots via a new ligand exchange free strategy. In addition to bioimaging, ZnO QDs have also been evaluated as a platform for targeted and pH responsive intracellular delivery of an anticancer drug. The cancer targeting feature is endowed by conjugating folic acid on to the surface of ZnO-NH2 QDs via an amidation reaction. Doxorubicin (DOX) is then successfully loaded onto the folic acid functionalized ZnO QDs by capitalizing on its marked tendency towards the formation of metal complexes. Drug loaded ZnO-FA QDs remain stable at physiological pH but readily disintegrate in the mildly acidic intracellular environment of cancer cells as validated by a drug release profile, confocal microscopy and a cell-cytotoxicity assay. Compared to the conventional drug nanovector, ZnO-FA QDs themselves manifest a significant therapeutic activity after reaching their targeted site, therefore, combined DOX and ZnO QDs can be more efficacious than either alone. Hence, this approach provides a valuable ZnO QDs-based nanovector that can simultaneously realize targeting, diagnosis, and therapy of cancer cells.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom13406
dc.relation.ispartofpageto13412
dc.relation.ispartofissue35
dc.relation.ispartofjournalJournal of Materials Chemistry
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchInorganic Chemistry not elsewhere classified
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode030299
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode09
dc.titleAcid degradable ZnO quantum dots as a platform for targeted delivery of an anticancer drug
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorZhao, Huijun
gro.griffith.authorZhu, Guangshan


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