dc.contributor.author | Herrero, Lara J | |
dc.contributor.author | Nelson, Michelle | |
dc.contributor.author | Srikiatkhachorn, Anon | |
dc.contributor.author | Gu, Ran | |
dc.contributor.author | Anantapreecha, Surapee | |
dc.contributor.author | Fingerle-Rowson, Guenter | |
dc.contributor.author | Bucala, Richard | |
dc.contributor.author | Morand, Eric | |
dc.contributor.author | Santos, Leilani L | |
dc.contributor.author | Mahalingam, Suresh | |
dc.date.accessioned | 2017-05-03T14:38:07Z | |
dc.date.available | 2017-05-03T14:38:07Z | |
dc.date.issued | 2011 | |
dc.date.modified | 2012-04-10T23:44:14Z | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.doi | 10.1073/pnas.1101089108 | |
dc.identifier.uri | http://hdl.handle.net/10072/44391 | |
dc.description.abstract | Arthrogenic alphaviruses, such as Ross River virus (RRV), chikungunya, Sindbis, mayaro and o'nyong-nyong viruses circulate endemically worldwide, frequently causing outbreaks of polyarthritis. The exact mechanisms of how alphaviruses induce polyarthritis remain ill defined, although macrophages are known to play a key role. Macrophage migration inhibitory factor (MIF) is an important cytokine involved in rheumatoid arthritis pathogenesis. Here, we characterize the role of MIF in alphavirus-induced arthritides using a mouse model of RRV-induced arthritis, which has many characteristics of RRV disease in humans. RRV-infected WT mice developed severe disease associated with up-regulated MIF expression in serum and tissues, which corresponded to severe inflammation and tissue damage. MIF-deficient (MIF-/-) mice developed mild disease accompanied by a reduction in inflammatory infiltrates and muscle destruction in the tissues, despite having viral titers similar to WT mice. In addition, reconstitution of MIF into MIF-/- mice exacerbated RRV disease and treatment of mice with MIF antagonist ameliorated disease in WT mice. Collectively, these findings suggest that MIF plays a critical role in determining the clinical severity of alphavirus-induced musculoskeletal disease and may provide a target for the development of antiviral pharmaceuticals. The prospect being that early treatment with MIF-blocking pharmaceuticals may curtail the debilitating arthritis associated with alphaviral infections. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | National Academy of Sciences | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 12048 | |
dc.relation.ispartofpageto | 12053 | |
dc.relation.ispartofissue | 29 | |
dc.relation.ispartofjournal | Proceedings of the National Academy of Sciences of USA | |
dc.relation.ispartofvolume | 108 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Humoural immunology and immunochemistry | |
dc.subject.fieldofresearchcode | 320405 | |
dc.title | Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Office of the Snr Dep Vice Chancellor, Institute for Glycomics | |
gro.date.issued | 2011 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Mahalingam, Suresh | |
gro.griffith.author | Herrero, Lara J. | |