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dc.contributor.authorHsu, JY-C
dc.contributor.authorChen, AC-H
dc.contributor.authorKeleher, A
dc.contributor.authorMcMillan, NAJ
dc.contributor.authorAntonsson, A
dc.date.accessioned2017-05-03T14:56:51Z
dc.date.available2017-05-03T14:56:51Z
dc.date.issued2009
dc.date.modified2012-05-29T22:40:56Z
dc.identifier.issn0146-6615
dc.identifier.doi10.1002/jmv.21529
dc.identifier.urihttp://hdl.handle.net/10072/44444
dc.description.abstractCutaneous human papillomavirus (HPV) types are commonly found in normal skin, and some of them have been suspected to play a role in the development of non-melanoma skin cancer. This present study is divided into three sections, the aims of this study were to examine if certain HPV-types persist over time and if HPV-types are shared within families. From the first part of the study, swab samples from foreheads were collected for three longitudinal studies from one family with a newborn baby. Five specific HPV-types were isolated from the family with a newborn, with HPV-5 and FA67 being found at various time points and prevalence rates in all four members of the family. Part 2 consisted of a followed up study from two families with a 6 years interval. Six of the family members were found to have at least one of the HPV-types identified in the family 6 years earlier. Many of the HPV-types identified were shared within the families studied. Part 3 of this study involved weekly samples from four healthy females for 4 months. Among the four healthy individuals, 11%, 65%, and 56% of the weekly samples were HPV-DNA positive with one individual HPV-negative. All specimens were tested for HPV-DNA by PCR using the broad range HPV-type primer pair FAP59/64. The positive samples were HPV-type determined by cloning and sequencing. Specific cutaneous HPV-types persist over long periods of time in healthy skin in most individuals investigated and certain HPVs are shared between family members.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent200775 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1444
dc.relation.ispartofpageto1449
dc.relation.ispartofissue8
dc.relation.ispartofjournalJournal of Medical Virology
dc.relation.ispartofvolume81
dc.rights.retentionY
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchMedical microbiology not elsewhere classified
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode320799
dc.titleShared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2009 Wiley Periodicals Inc. This is the pre-peer reviewed version of the following article: Shared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin, Journal of Medical Virology, Vol. 81(8), 2009, pp. 1444-1449, which has been published in final form at http://dx.doi.org/10.1002/jmv.21529.
gro.date.issued2009
gro.hasfulltextFull Text
gro.griffith.authorMcMillan, Nigel


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