dc.contributor.author | Hsu, JY-C | |
dc.contributor.author | Chen, AC-H | |
dc.contributor.author | Keleher, A | |
dc.contributor.author | McMillan, NAJ | |
dc.contributor.author | Antonsson, A | |
dc.date.accessioned | 2017-05-03T14:56:51Z | |
dc.date.available | 2017-05-03T14:56:51Z | |
dc.date.issued | 2009 | |
dc.date.modified | 2012-05-29T22:40:56Z | |
dc.identifier.issn | 0146-6615 | |
dc.identifier.doi | 10.1002/jmv.21529 | |
dc.identifier.uri | http://hdl.handle.net/10072/44444 | |
dc.description.abstract | Cutaneous human papillomavirus (HPV) types are commonly found in normal skin, and some of them have been suspected to play a role in the development of non-melanoma skin cancer. This present study is divided into three sections, the aims of this study were to examine if certain HPV-types persist over time and if HPV-types are shared within families. From the first part of the study, swab samples from foreheads were collected for three longitudinal studies from one family with a newborn baby. Five specific HPV-types were isolated from the family with a newborn, with HPV-5 and FA67 being found at various time points and prevalence rates in all four members of the family. Part 2 consisted of a followed up study from two families with a 6 years interval. Six of the family members were found to have at least one of the HPV-types identified in the family 6 years earlier. Many of the HPV-types identified were shared within the families studied. Part 3 of this study involved weekly samples from four healthy females for 4 months. Among the four healthy individuals, 11%, 65%, and 56% of the weekly samples were HPV-DNA positive with one individual HPV-negative. All specimens were tested for HPV-DNA by PCR using the broad range HPV-type primer pair FAP59/64. The positive samples were HPV-type determined by cloning and sequencing. Specific cutaneous HPV-types persist over long periods of time in healthy skin in most individuals investigated and certain HPVs are shared between family members. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 200775 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | John Wiley & Sons, Inc. | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1444 | |
dc.relation.ispartofpageto | 1449 | |
dc.relation.ispartofissue | 8 | |
dc.relation.ispartofjournal | Journal of Medical Virology | |
dc.relation.ispartofvolume | 81 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Microbiology | |
dc.subject.fieldofresearch | Medical microbiology | |
dc.subject.fieldofresearch | Medical microbiology not elsewhere classified | |
dc.subject.fieldofresearchcode | 3107 | |
dc.subject.fieldofresearchcode | 3207 | |
dc.subject.fieldofresearchcode | 320799 | |
dc.title | Shared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2009 Wiley Periodicals Inc. This is the pre-peer reviewed version of the following article: Shared and persistent asymptomatic cutaneous human papillomavirus infections in healthy skin, Journal of Medical Virology, Vol. 81(8), 2009, pp. 1444-1449, which has been published in final form at http://dx.doi.org/10.1002/jmv.21529. | |
gro.date.issued | 2009 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | McMillan, Nigel | |