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dc.contributor.authorMenon, Saras
dc.contributor.authorButeri, Jennifer
dc.contributor.authorRoy, Bishakha
dc.contributor.authorMurrell, Melanie
dc.contributor.authorQuinlan, Sharon
dc.contributor.authorMacMillan, John
dc.contributor.authorLea, Rodney
dc.contributor.authorHaupt, Larisa
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-03T12:28:01Z
dc.date.available2017-05-03T12:28:01Z
dc.date.issued2011
dc.date.modified2012-04-11T22:32:33Z
dc.identifier.issn00068993
dc.identifier.doi10.1016/j.brainres.2010.12.072
dc.identifier.urihttp://hdl.handle.net/10072/44446
dc.description.abstractMigraine is a neurological disorder that is associated with increased levels of calcitonin gene-related peptide (CGRP) in plasma. CGRP, being one of the mediators of neurogenic inflammation and a phenomenon implicated in the pathogenesis of migraine headache, is thus suggested to have an important role in migraine pathophysiology. Polymorphisms of the CALCA gene have been linked to Parkinson's disease, ovarian cancer and essential hypertension, suggesting a functional role for these polymorphisms. Given the strong evidence linking CGRP and migraine, it is hypothesised that polymorphisms in the CALCA gene may play a role in migraine pathogenesis. Seemingly non functional intronic polymorphisms are capable of disrupting normal RNA processing or introducing a splice site in the transcript. A 16 bp deletion in the first intron of the CALCA gene has been reported to be a good match for the binding site for a transcription factor expressed strongly in neural crest derived cells, AP-2. This deletion also eliminates an intron splicing enhancer (ISE) that may potentially cause exon skipping. This study investigated the role of the 16 bp intronic deletion in the CALCA gene in migraineurs and matched control individuals. Six hundred individuals were genotyped for the deletion by polymerase chain reaction followed by fragment analysis on the 3130 Genetic Analyser. The results of this study showed no significant association between the intronic 16 bp deletion in the CALCA gene and migraine in the tested Australian Caucasian population. However, given the evidence linking CGRP and migraine, further investigation of variants with this gene may be warranted.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom119
dc.relation.ispartofpageto124
dc.relation.ispartofjournalBrain Research
dc.relation.ispartofvolume1378
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode110999
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.titleAssociation study of calcitonin gene-related polypeptide-alpha (CALCA) gene polymorphism with migraine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorHaupt, Larisa
gro.griffith.authorMacMillan, John C.
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorQuinlan, Sharon A.
gro.griffith.authorLea, Rodney A.
gro.griffith.authorMenon, Saras
gro.griffith.authorButeri, Jennifer S.
gro.griffith.authorRoy, Bishakha
gro.griffith.authorMurrell, Melanie J.


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