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dc.contributor.authorBurne, THJ
dc.contributor.authorMcGrath, JJ
dc.contributor.authorEyles, DW
dc.contributor.authorMackay-Sim, A
dc.date.accessioned2017-05-03T11:32:29Z
dc.date.available2017-05-03T11:32:29Z
dc.date.issued2005
dc.date.modified2009-09-22T05:51:49Z
dc.identifier.issn0166-4328
dc.identifier.doi10.1016/j.bbr.2004.07.008
dc.identifier.urihttp://hdl.handle.net/10072/4451
dc.description.abstractVitamin D (calcitriol) is a nuclear transcription regulator acting via a nuclear hormone receptor (VDR). In addition to its role in the regulation of calcium and phosphate homeostasis and in bone formation, Vitamin D is also thought to be involved in brain function. The aim of this study was to behaviourally phenotype VDR knockout mice. We characterized the behaviour of VDR null mutant mice and wildtype littermate controls by subjecting them to a range of tests including a primary behavioural screen (using the SHIRPA protocol), rotarod, gait analysis, Y-maze, marble burying test, bedding test, holeboard test, elevated plus maze, open field test and prepulse inhibition of the acoustic startle response. There were no effects of genotype on most of the scores from the SHIRPA protocol except that VDR -/- mice had alopecia, were shorter and weighed less than VDR +/+ mice. VDR -/- mice had a shorter gait as well as impairments on the rotarod, in the bedding test and impaired habituation in both the open field and on the acoustic startle response. The VDR -/- mice had normal acoustic startle responses but had impaired PPI at long (256 ms) but not short (64 ms) prepulse to pulse intervals. The VDR -/- mice were less active in the open field and buried fewer marbles in the marble burying test. However, there were no differences in the time spent on the open arms of the elevated plus maze or in working memory as assessed by repeat arm entries on the Y-maze. Therefore, it appears that VDR -/- mice have muscular and motor impairments that significantly affects locomotor behaviour but seemingly no impairments in cognition as indicated by exploration, working memory or anxiety.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.sciencedirect.com/science/journal/01664328
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom299
dc.relation.ispartofpageto308
dc.relation.ispartofjournalBehavioural Brain Research
dc.relation.ispartofvolume157
dc.rights.retentionN
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.titleBehavioural characterization of vitamin D receptor knockout mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan


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