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  • Developmental Vitamin D3 deficiency alters the adult rat brain

    Author(s)
    Feron, F
    Burne, THJ
    Brown, J
    Smith, E
    McGrath, JJ
    Mackay-Sim, A
    Eyles, DW
    Griffith University Author(s)
    Mackay-Sim, Alan
    Year published
    2005
    Metadata
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    Abstract
    There is growing evidence that Vitamin D(3) (1,25-dihydroxyvitamin D(3)) is involved in brain development. We have recently shown that the brains of newborn rats from Vitamin D(3) deficient dams were larger than controls, had increased cell proliferation, larger lateral ventricles, and reduced cortical thickness. Brains from these animals also had reduced expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor. The aim of the current study was to examine if there were any permanent outcomes into adulthood when the offspring of Vitamin D(3) deficient dams were restored to a normal diet. The ...
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    There is growing evidence that Vitamin D(3) (1,25-dihydroxyvitamin D(3)) is involved in brain development. We have recently shown that the brains of newborn rats from Vitamin D(3) deficient dams were larger than controls, had increased cell proliferation, larger lateral ventricles, and reduced cortical thickness. Brains from these animals also had reduced expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor. The aim of the current study was to examine if there were any permanent outcomes into adulthood when the offspring of Vitamin D(3) deficient dams were restored to a normal diet. The brains of adult rats were examined at 10 weeks of age after Vitamin D(3) deficiency until birth or weaning. Compared to controls animals that were exposed to transient early Vitamin D(3) deficiency had larger lateral ventricles, reduced NGF protein content, and reduced expression of a number genes involved in neuronal structure, i.e. neurofilament or MAP-2 or neurotransmission, i.e. GABA-A(alpha4). We conclude that transient early life hypovitaminosis D(3) not only disrupts brain development but leads to persistent changes in the adult brain. In light of the high incidence of hypovitaminosis D(3) in women of child-bearing age, the public health implications of these findings warrant attention.
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    Journal Title
    Brain Research Bulletin
    Volume
    65
    Issue
    2
    Publisher URI
    http://www.sciencedirect.com/science/journal/03619230
    DOI
    https://doi.org/10.1016/j.brainresbull.2004.12.007
    Subject
    Neurosciences
    Cognitive and computational psychology
    Publication URI
    http://hdl.handle.net/10072/4453
    Collection
    • Journal articles

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