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  • Novel bacterial MerR-like regulators: their role in the response to carbonyl and nitrosative stress

    Author(s)
    McEwan, Alastair G
    Djoko, Karrera Y
    Chen, Nathan H
    Counago, Rafael LM
    Kidd, Stephen P
    Potter, Adam J
    Jennings, Michael P
    Griffith University Author(s)
    Jennings, Michael P.
    Year published
    2011
    Metadata
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    Abstract
    Recognition of the diversity of transcriptional regulators of the MerR family has increased considerably over the last decade and it has been established that not all MerR-like regulators are involved in metal ion recognition. A new type of MerR-like regulator was identified in Neisseria gonorrhoeae that is distinct from metal-binding MerR proteins. This novel transcription factor, the Neisseria merR-like regulator (NmlR) is related to a large and diverse group of MerR-like regulators. A common feature of the majority of the genes encoding the nmlR-related genes is that they predicted to control the expression of adhC, which ...
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    Recognition of the diversity of transcriptional regulators of the MerR family has increased considerably over the last decade and it has been established that not all MerR-like regulators are involved in metal ion recognition. A new type of MerR-like regulator was identified in Neisseria gonorrhoeae that is distinct from metal-binding MerR proteins. This novel transcription factor, the Neisseria merR-like regulator (NmlR) is related to a large and diverse group of MerR-like regulators. A common feature of the majority of the genes encoding the nmlR-related genes is that they predicted to control the expression of adhC, which encodes a glutathione-dependent alcohol dehydrogenase. The function of the NmlR regulon appears to be to defend the bacterial cell against carbonyl stress and in some cases nitrosative stress. A potential role for NmlR in bacterial pathogenesis has been identified in Neisseria gonorrhoeae and Streptococcus pneumoniae. Although it is not known how NmlR is activated it is suggested that conserved cysteine residues may be involved in thiol-based signaling.
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    Book Title
    Advances in Microbial Physiology
    Volume
    58
    DOI
    https://doi.org/10.1016/B978-0-12-381043-4.00001-5
    Copyright Statement
    Self-archiving is not yet supported by this publisher. Please refer to the publisher's website or contact the author(s) for more information.
    Subject
    Medical Microbiology not elsewhere classified
    Microbiology
    Publication URI
    http://hdl.handle.net/10072/44575
    Collection
    • Book chapters

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