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dc.contributor.authorG. McEwan, Alastairen_US
dc.contributor.authorY. Djoko, Karreraen_US
dc.contributor.authorH. Chen, Nathanen_US
dc.contributor.authorL.M. Counago, Rafaelen_US
dc.contributor.authorKidd, Stephen P.en_US
dc.contributor.authorJ. Potter, Adamen_US
dc.contributor.authorJennings, Michaelen_US
dc.contributor.editorRobert K Pooleen_US
dc.date.accessioned2017-05-16T12:30:31Z
dc.date.available2017-05-16T12:30:31Z
dc.date.issued2011en_US
dc.date.modified2012-04-22T22:19:04Z
dc.identifier.isbn9780123810434en_US
dc.identifier.doi10.1016/B978-0-12-381043-4.00001-5en_US
dc.identifier.urihttp://hdl.handle.net/10072/44575
dc.description.abstractRecognition of the diversity of transcriptional regulators of the MerR family has increased considerably over the last decade and it has been established that not all MerR-like regulators are involved in metal ion recognition. A new type of MerR-like regulator was identified in Neisseria gonorrhoeae that is distinct from metal-binding MerR proteins. This novel transcription factor, the Neisseria merR-like regulator (NmlR) is related to a large and diverse group of MerR-like regulators. A common feature of the majority of the genes encoding the nmlR-related genes is that they predicted to control the expression of adhC, which encodes a glutathione-dependent alcohol dehydrogenase. The function of the NmlR regulon appears to be to defend the bacterial cell against carbonyl stress and in some cases nitrosative stress. A potential role for NmlR in bacterial pathogenesis has been identified in Neisseria gonorrhoeae and Streptococcus pneumoniae. Although it is not known how NmlR is activated it is suggested that conserved cysteine residues may be involved in thiol-based signaling.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofbooktitleAdvances in Microbial Physiologyen_US
dc.relation.ispartofchapter1en_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto22en_US
dc.relation.ispartofvolume58en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Microbiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110899en_US
dc.titleNovel bacterial MerR-like regulators: their role in the response to carbonyl and nitrosative stressen_US
dc.typeBook chapteren_US
dc.type.descriptionB1 - Book Chapters (HERDC)en_US
dc.type.codeB - Book Chaptersen_US
gro.rights.copyrightSelf-archiving is not yet supported by this publisher. Please refer to the publisher's website or contact the author(s) for more information.en_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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