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  • The genetics of alphaviruses

    Author(s)
    Foo, Suan Sin
    Chen, Weiqiang
    Herrero, Lara
    Bettadapura, Jayaram
    Narayan, Jayasuryan
    Dar, Lalit
    Broor, Shobha
    Mahalingam, Suresh
    Griffith University Author(s)
    Mahalingam, Suresh
    Herrero, Lara J.
    Year published
    2011
    Metadata
    Show full item record
    Abstract
    Alphaviruses are emerging human pathogens that are transmitted by arthropod vectors. Their ability to infect a wide range of vertebrate hosts including humans, equines, birds and rodents has brought about a series of epidemic and epizootic outbreaks worldwide. Their potential to cause a pandemic has spurred the interest of researchers globally, leading to the rapid advancement on the characterization of genetic determinants of alphaviruses. In this review, the focal point is placed on the genetics of alphaviruses, whereby the genetic composition, clinical features, evolution and adaptation of alphaviruses, modulation of IFN ...
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    Alphaviruses are emerging human pathogens that are transmitted by arthropod vectors. Their ability to infect a wide range of vertebrate hosts including humans, equines, birds and rodents has brought about a series of epidemic and epizootic outbreaks worldwide. Their potential to cause a pandemic has spurred the interest of researchers globally, leading to the rapid advancement on the characterization of genetic determinants of alphaviruses. In this review, the focal point is placed on the genetics of alphaviruses, whereby the genetic composition, clinical features, evolution and adaptation of alphaviruses, modulation of IFN response by alphavirus proteins and therapeutic aspects of alphaviruses will be discussed.
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    Journal Title
    Future Virology
    Volume
    6
    Issue
    12
    DOI
    https://doi.org/10.2217/fvl.11.123
    Subject
    Microbiology
    Virology
    Medical microbiology
    Publication URI
    http://hdl.handle.net/10072/44603
    Collection
    • Journal articles

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