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dc.contributor.authorWykes, MN
dc.contributor.authorKay, JG
dc.contributor.authorManderson, A
dc.contributor.authorLiu, XQ
dc.contributor.authorBrown, DL
dc.contributor.authorRichard, DJ
dc.contributor.authorWipasa, J
dc.contributor.authorJiang, SH
dc.contributor.authorJones, MK
dc.contributor.authorJanse, CJ
dc.contributor.authorWaters, AP
dc.contributor.authorPierce, SK
dc.contributor.authorMiller, LH
dc.contributor.authorStow, JL
dc.contributor.authorGood, MF
dc.date.accessioned2017-05-03T15:04:59Z
dc.date.available2017-05-03T15:04:59Z
dc.date.issued2011
dc.date.modified2012-04-23T21:56:21Z
dc.identifier.issn0027-8424
dc.identifier.doi10.1073/pnas.1108579108
dc.identifier.urihttp://hdl.handle.net/10072/44612
dc.description.abstractPlasmodium spp. parasites cause malaria in 300 to 500 million individuals each year. Disease occurs during the blood-stage of the parasite's life cycle, where the parasite is thought to replicate exclusively within erythrocytes. Infected individuals can also suffer relapses after several years, from Plasmodium vivax and Plasmodium ovale surviving in hepatocytes. Plasmodium falciparum and Plasmodium malariae can also persist after the original bout of infection has apparently cleared in the blood, suggesting that host cells other than erythrocytes (but not hepatocytes) may harbor these blood-stage parasites, thereby assisting their escape from host immunity. Using blood stage transgenic Plasmodium berghei-expressing GFP (PbGFP) to track parasites in host cells, we found that the parasite had a tropism for CD317+ dendritic cells. Other studies using confocal microscopy, in vitro cultures, and cell transfer studies showed that blood-stage parasites could infect, survive, and replicate within CD317+ dendritic cells, and that small numbers of these cells released parasites infectious for erythrocytes in vivo. These data have identified a unique survival strategy for blood-stage Plasmodium, which has significant implications for understanding the escape of Plasmodium spp. from immune-surveillance and for vaccine development.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNational Academy of Sciences
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom11205
dc.relation.ispartofpageto11210
dc.relation.ispartofissue27
dc.relation.ispartofjournalProceedings of the National Academy of Sciences
dc.relation.ispartofvolume108
dc.rights.retentionY
dc.subject.fieldofresearchInfectious agents
dc.subject.fieldofresearchcode310702
dc.titleRodent blood-stage Plasmodium survive in dendritic cells that infect naive mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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