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dc.contributor.authorWykes, Michelleen_US
dc.contributor.authorG. Kay, Jasonen_US
dc.contributor.authorManderson, Anthonyen_US
dc.contributor.authorLiu, Xueqinen_US
dc.contributor.authorL. Brown, Darrenen_US
dc.contributor.authorRichard, Dereken_US
dc.contributor.authorWipasa, Jiraprapaen_US
dc.contributor.authorH. Jiang, Suhuaen_US
dc.contributor.authorJones, Malcolmen_US
dc.contributor.authorJ. Janse, Chrisen_US
dc.contributor.authorP. Waters, Andrewen_US
dc.contributor.authorK. Pierce, Susanen_US
dc.contributor.authorMiller, Louis H.en_US
dc.contributor.authorL. Stow, Jenniferen_US
dc.contributor.authorGood, Michaelen_US
dc.description.abstractPlasmodium spp. parasites cause malaria in 300 to 500 million individuals each year. Disease occurs during the blood-stage of the parasite's life cycle, where the parasite is thought to replicate exclusively within erythrocytes. Infected individuals can also suffer relapses after several years, from Plasmodium vivax and Plasmodium ovale surviving in hepatocytes. Plasmodium falciparum and Plasmodium malariae can also persist after the original bout of infection has apparently cleared in the blood, suggesting that host cells other than erythrocytes (but not hepatocytes) may harbor these blood-stage parasites, thereby assisting their escape from host immunity. Using blood stage transgenic Plasmodium berghei-expressing GFP (PbGFP) to track parasites in host cells, we found that the parasite had a tropism for CD317+ dendritic cells. Other studies using confocal microscopy, in vitro cultures, and cell transfer studies showed that blood-stage parasites could infect, survive, and replicate within CD317+ dendritic cells, and that small numbers of these cells released parasites infectious for erythrocytes in vivo. These data have identified a unique survival strategy for blood-stage Plasmodium, which has significant implications for understanding the escape of Plasmodium spp. from immune-surveillance and for vaccine development.en_US
dc.publisherNational Academy of Sciencesen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofjournalProceedings of the National Academy of Sciencesen_US
dc.subject.fieldofresearchInfectious Agentsen_US
dc.titleRodent blood-stage Plasmodium survive in dendritic cells that infect naive miceen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.hasfulltextNo Full Text

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