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dc.contributor.authorBurns, Andrew A
dc.contributor.authorVider, Jelena
dc.contributor.authorOw, Hooisweng
dc.contributor.authorHerz, Erik
dc.contributor.authorPenate-Medina, Oula
dc.contributor.authorBaumgart, Martin
dc.contributor.authorLarson, Steven M
dc.contributor.authorWiesner, Ulrich
dc.contributor.authorBradbury, Michelle
dc.date.accessioned2017-05-03T16:06:19Z
dc.date.available2017-05-03T16:06:19Z
dc.date.issued2009
dc.date.modified2012-05-09T23:00:29Z
dc.identifier.issn1530-6984
dc.identifier.doi10.1021/nl803405h
dc.identifier.urihttp://hdl.handle.net/10072/44722
dc.description.abstractThe development of molecularly targeted probes that exhibit high biostability, biocompatibility, and efficient clearance profiles is key to optimizing biodistribution and transport across biological barriers. Further, coupling probes designed to meet these criteria with high-sensitivity, quantitative imaging strategies is mandatory for ensuring early in vivo tumor detection and timely treatment response. These challenges have often only been examined individually, impeding the clinical translation of fluorescent probes. By simultaneously optimizing these design criteria, we created a new generation of near-infrared fluorescent core-shell silica-based nanoparticles (C dots) tuned to hydrodynamic diameters of 3.3 and 6.0 nm with improved photophysical characteristics over the parent dye. A neutral organic coating prevented adsorption of serum proteins and facilitated efficient urinary excretion. Detailed particle biodistribution studies were performed using more quantitative ex vivo fluorescence detection protocols and combined optical-PET imaging. The results suggest that this new generation of C dots constitutes a promising clinically translatable materials platform which may be adapted for tumor targeting and treatment.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom442
dc.relation.ispartofpageto448
dc.relation.ispartofissue1
dc.relation.ispartofjournalNano Letters
dc.relation.ispartofvolume9
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchcode119999
dc.titleFluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
gro.date.issued2009
gro.hasfulltextNo Full Text
gro.griffith.authorVider, Jelena


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