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dc.contributor.authorJedlinski, Dominiken_US
dc.contributor.authorGabrovska, Pamen_US
dc.contributor.authorWeinstein, Stephenen_US
dc.contributor.authorSmith, Roberten_US
dc.contributor.authorGriffiths, Lynen_US
dc.date.accessioned2017-05-03T12:00:19Z
dc.date.available2017-05-03T12:00:19Z
dc.date.issued2011en_US
dc.date.modified2013-05-30T04:05:11Z
dc.identifier.issn18324274en_US
dc.identifier.doi10.1375/twin.14.5.417en_US
dc.identifier.urihttp://hdl.handle.net/10072/44724
dc.description.abstractmicroRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA's properties and/or maturation may change. miR-196a has been reported to be aberrantly expressed in breast cancer tissue. Additionally, the SNP rs11614913 in hsa-mir-196a-2 has been found to be associated with breast cancer risk in some studies although not in others. This study evaluated the association between rs11614913 and breast cancer risk in a Caucasian case-control cohort in Queensland, Australia. Results do not support an association of the tested hsa-mir-196a-2 polymorphism with breast cancer susceptibility in this cohort. As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent570408 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherCambridge University Pressen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom417en_US
dc.relation.ispartofpageto421en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalTwin Research and Human Geneticsen_US
dc.relation.ispartofvolume14en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchGenome Structure and Regulationen_US
dc.subject.fieldofresearchcode060407en_US
dc.titleSingle Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Studyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright 2011 Cambridge University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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