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dc.contributor.authorQuan, Jingjingen_US
dc.contributor.authorJohnson, Newellen_US
dc.contributor.authorZhou, Guangbiaoen_US
dc.contributor.authorParsons, Peteren_US
dc.contributor.authorBoyle, Glenen_US
dc.contributor.authorGao, Jinen_US
dc.date.accessioned2017-05-03T12:00:13Z
dc.date.available2017-05-03T12:00:13Z
dc.date.issued2012en_US
dc.date.modified2014-08-28T05:06:29Z
dc.identifier.issn01677659en_US
dc.identifier.doi10.1007/s10555-011-9335-7en_US
dc.identifier.urihttp://hdl.handle.net/10072/44796
dc.description.abstractAbstract Bone invasion is a common characteristic of oral squamous cell carcinoma (OSCC), with adverse affects on patient functionality and survival. Recent studies suggest that it is osteoclasts, rather than malignant keratinocytes themselves, which play the major role in facilitating the entry of the tumour into bone, and its progression within bone. Osteoclasts respond to a variety of local signalling pathways, initiated by products of the malignant epithelial cells. In the present review, we firstly introduce the clinical patterns of bone invasion, and then summarise these signalling pathways and their diverse roles in sequential phases of bone invasion. We also review current researches regarding the incidence and mechanisms of distant metastases to bone, and explain briefly the concept of epithelialmesenchymal transition, which may generate cancer stem cells and initiate the bone invasion. Finally, we discuss more briefly approaches to the diagnosis and management of OSCC patients with bone invasion. With all these studies and some recent discoveries in our own laboratory, an enhanced understanding of bone invasion will be achieved, which should indicate potential molecular targets for future biotherapies.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent478674 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherSpringer New York LLCen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom209en_US
dc.relation.ispartofpageto219en_US
dc.relation.ispartofissue1-2en_US
dc.relation.ispartofjournalCancer and Metastasis Reviewsen_US
dc.relation.ispartofvolume31en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titlePotential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanismsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Dentistry and Oral Healthen_US
gro.rights.copyright© 2011 Springer Netherlands. This is an electronic version of an article published in Cancer and Metastasis Reviews, June 2012, Volume 31, Issue 1-2, pp 209-219. Cancer and Metastasis Reviews is available online at: http://www.springerlink.com/ with the open URL of your article.en_US
gro.date.issued2012
gro.hasfulltextFull Text


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