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  • Cytotoxic Evaluation of Alkaloids and Isoflavonoids from the Australian Tree Erythrina vespertilio

    Author(s)
    Iranshahi, Mehrdad
    Hoan, Vu
    Ngoc, Pham
    Zencak, Dusan
    Forster, Paul
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Pham, Ngoc B.
    Vu, Hoan T.
    Iranshahi, Mehrdad
    Zencak, Dusan
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11-߭methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth. In addition, three known isoflavonoids, including phaseollin, alpiniumisoflavone, and phaseollidin, were identified from the plant stems. The structures of compounds were determined by 1D/2D NMR and mass experiments. The cytotoxic activity of all compounds was evaluated against a metastatic prostate cancer cell line (PC3) and neonatal foreskin fibroblast (NFF) using a real-time label-free cell analyser. Among the tested compounds, ...
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    A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11-߭methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth. In addition, three known isoflavonoids, including phaseollin, alpiniumisoflavone, and phaseollidin, were identified from the plant stems. The structures of compounds were determined by 1D/2D NMR and mass experiments. The cytotoxic activity of all compounds was evaluated against a metastatic prostate cancer cell line (PC3) and neonatal foreskin fibroblast (NFF) using a real-time label-free cell analyser. Among the tested compounds, phaseollidin showed cytotoxic activities against PC3 (IC50 = 8.83 ᠱ.87 卩 and NFF (0.64 ᠰ.37 卩 cell lines.
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    Journal Title
    Planta Medica: natural products and medicinal plant research
    Volume
    78
    Issue
    7
    DOI
    https://doi.org/10.1055/s-0031-1298310
    Subject
    Biologically active molecules
    Plant biology
    Traditional, complementary and integrative medicine
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/44824
    Collection
    • Journal articles

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