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dc.contributor.authorAhmed, F
dc.contributor.authorKhan, MR
dc.contributor.authorAkhtaruzzaman, M
dc.contributor.authorKarim, R
dc.contributor.authorWilliams, G
dc.contributor.authorTorlesse, H
dc.contributor.authorDarnton-Hill, I
dc.contributor.authorDalmiya, N
dc.contributor.authorBanu, CP
dc.contributor.authorNahar, B
dc.date.accessioned2017-05-03T14:56:52Z
dc.date.available2017-05-03T14:56:52Z
dc.date.issued2010
dc.date.modified2012-06-07T22:10:23Z
dc.identifier.issn0022-3166
dc.identifier.doi10.3945/jn.109.119123
dc.identifier.urihttp://hdl.handle.net/10072/44874
dc.description.abstractPrevious short-term supplementation studies showed no additional hematologic benefit of multiple micronutrients (MMN) compared with iron + folic acid (IFA) in adolescent girls. This study examines whether long-term once- or twice-weekly supplementation of MMN can improve hemoglobin (Hb) and micronutrient status more than twice-weekly IFA supplementation in anemic adolescent girls in Bangladesh. Anemic girls (n = 324) aged 11-17 y attending rural schools were given once- or twice-weekly MMN or twice-weekly IFA, containing 60 mg iron/dose in both supplements, for 52 wk in a randomized double-blind trial. Blood samples were collected at baseline and 26 and 52 wk. Intent to treat analysis showed no significant difference in the Hb concentration between treatments at either 26 or 52 wk. However, after excluding girls with hemoglobinopathy and adjustment for baseline Hb, a greater increase in Hb was observed with twice-weekly MMN at 26 wk (P = 0.045). Although all 3 treatments effectively reduced iron deficiency, once-weekly MMN produced significantly lower serum ferritin concentrations than the other treatments at both 26 and 52 wk. Both once- and twice-weekly MMN significantly improved riboflavin, vitamin A, and vitamin C status compared with IFA. Overall, once-weekly MMN was less efficacious than twice-weekly MMN in improving iron, riboflavin, RBC folic acid, and vitamin A levels. Micronutrient supplementation beyond 26 wk was likely important in sustaining improved micronutrient status. These findings highlight the potential usefulness of MMN intervention in this population and have implications for programming.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Nutrition
dc.publisher.placeUnited States
dc.publisher.urihttp://jn.nutrition.org/content/140/10/1879.abstract
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1879
dc.relation.ispartofpageto1886
dc.relation.ispartofissue10
dc.relation.ispartofjournalThe Journal of Nutrition
dc.relation.ispartofvolume140
dc.rights.retentionY
dc.subject.fieldofresearchAnimal production
dc.subject.fieldofresearchFood sciences
dc.subject.fieldofresearchNutrition and dietetics
dc.subject.fieldofresearchNutrition and dietetics not elsewhere classified
dc.subject.fieldofresearchcode3003
dc.subject.fieldofresearchcode3006
dc.subject.fieldofresearchcode3210
dc.subject.fieldofresearchcode321099
dc.titleLong-Term Intermittent Multiple Micronutrient Supplementation Enhances Hemoglobin and Micronutrient Status More Than Iron plus Folic Acid Supplementation in Bangladeshi Rural Adolescent Girls with Nutritional Anemia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorAhmed, Faruk


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